iPTMnet Report for Q9Y223 (GNE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9Y223 / GLCNE_HUMAN
Protein Name Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Gene Name Name: GNE
Synonyms:GLCNE;
Organism Homo sapiens (Human)

PRO ID PR:Q9Y223
DAG View
PRO Name bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (human)
Definition A bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase that is encoded in the genome of human.
Short Label hGNE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9Y223 (GNE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y22 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y197 Phosphorylation HPRD 20068231
S199 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K22 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S199 I199 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K385 N385 Biomuta DOID:363 / uterine cancer [ cosmic ]
K440 N440 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K637 N637 Biomuta DOID:9256 / colorectal cancer [ cosmic ]