Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9WV60 / GSK3B_MOUSE
Protein Name Glycogen synthase kinase-3 beta
Gene Name Name: Gsk3b
Organism Mus musculus (Mouse)

PRO ID PR:Q9WV60
DAG View
PRO Name glycogen synthase kinase-3 beta (mouse)
Definition A glycogen synthase kinase-3 beta that is encoded in the genome of mouse.
Short Label mGSK3B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9WV60 (Gsk3b) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation phospho.ELM   PhosphoSitePlus 17242355
T8 Phosphorylation PhosphoSitePlus
S9 Phosphorylation Q8BSK8 (Rps6kb1) , P31750 (Akt1) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 23369342, 23853095, 21079728, ...21601837, 27259701, 26582204, 29127434, 21445308, 24391509, 25594415, 15888552, 22434044, 21998135, 18322105, 25331948, 23884889, 19356803, 26095336, 21796107, 16530186, 25942043, 22114306, 16489037, 23807397, 15791206, 24788685, 20016849, 21460223, 23301857, 23593332, 20332342, 22536363, 25073924, 19939226, 24923837, 22768254, 16522636, 24810941, 12489109, 22258319, 28368015, 22188973, 19106302, 22672822, 25355398, 25463972, 25775433, 25029272, 17241269, 22785175, 27294914, 25738875, 17053159, 17975737, 27589526, 25972359, 15039769, 27799526, 22383997, 15980066, 24325618, 21544852, 26342176, 24278135, 25902782, 17289030, 23082110, 26996481, 12504922, 23668310, 23395175, 16565488, 16374520, 27568038, 12095987, 24227739, 26118757, 22714712, 15961082, 25115838, 29753049, 22249311, 23965299, 25107557, 21671257, 15878878, 26798521, 24454979, 26950856, 28832021, 26750157, 29452207, 28920384, 26521867, 26872261, 21044639, 28128361, 21540081, 27050422, 27374489, 24614172, 28461774, 17699780, 27287266, 29223528, 24340001, 28005221, 21364645, 18801732, 23239877, 24913231, 16987252, 26822034, 25132272, 18616990, 19818092, 24670930, 21659643, 22238573, 11035810, 26785133, 24223757, 25172181, 18824542, 28197064, 22064483, 22022450, 16510873, 15659239, 26413814, 23816813, 26883430, 14745448, 23455548, 15845746, 16762022, 28422052, 17597257, 27612601, 21843906, 26854125, 20690801, 21072211, 28240305, 17560576, 22057101, 17475833, 27694908, 22471389, 24025512, 22073301, 16039605, 24462873, 27074656, 29670081, 17052453, 19328817, 27001940, 23444402, 24952363, 29058041, 17141160, 28146408, 26728762, 18701453, 26738851, 20592205, 17714451, 24440987, 27688851, 25412623, 27162139, 27497480, 27488110, 25443285, 26454089, 22356228, 26695202, 24915968, 19230830, 16434614, 25899687, 27778132, 14522959, 20111716, 27378458, 23700479, 21821713, 23144711
S13 Phosphorylation PhosphoSitePlus
S21 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 26393344, 22022450, 15710331, ...22434044, 15659239, 22238573, 20300527, 23239877, 19328817, 25073924, 19939226
S25 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
S215 Phosphorylation phospho.ELM   PhosphoSitePlus 17114649
Y216 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 27694908, 27050422, 12937146, ...27287266, 17242355, 29670081, 21445308, 21998135, 19818092, 22096577, 26785133, 25172181, 28197064, 28207769, 22422579, 25047000, 15592455, 25443285, 21671257, 22536363, 24923837, 16855914, 24810941, 26274564, 21843906, 23628704, 17114649, 28240305, 23028846, 23661004
S219 Phosphorylation phospho.ELM   PhosphoSitePlus 17242355
K292 Ubiquitination PhosphoSitePlus
C317 S-Nitrosylation dbSNO 21278135
T356 Phosphorylation PhosphoSitePlus   RLIMS-P 25477508
S389 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17114649, 15345747, 28832021, ...26822034
T395 Phosphorylation phospho.ELM   PhosphoSitePlus 17114649


Q9WV60 (Gsk3b) as PTM Enzyme



Substrate Site Score Source PMID
O08553 (Dpysl2) T509 PhosphoSitePlus 16611631
O08553 (Dpysl2) T514 PhosphoSitePlus 16611631
O08586 (Pten) T366 PhosphoSitePlus 20940307
O35625 (Axin1) T480 PhosphoSitePlus 10581160
O35625 (Axin1) S485 PhosphoSitePlus 10581160
P01108 (Myc) T58 PhosphoSitePlus 19223464
P05627 (Jun) T242 PhosphoSitePlus 12881422
P05627 (Jun) S246 PhosphoSitePlus 12881422
P06876 (Myb) T572 PhosphoSitePlus 21092141
P14719 (Il1rl1) S442 RLIMS-P+ 22660580
P14873 (Map1b) S1260 PhosphoSitePlus 15731007
P14873 (Map1b) T1265 PhosphoSitePlus 15731007
P23204 (Ppara) S73 RLIMS-P+ 27738106
P23804 (Mdm2) S240 PhosphoSitePlus 16055726
P23804 (Mdm2) S254 PhosphoSitePlus 16055726
P25322 (Ccnd1) T286 PhosphoSitePlus 11124803, 15075324
P25322 (Ccnd1) T288 PhosphoSitePlus 15075324
P28033 (Cebpb) T179 PhosphoSitePlus 17601773, 17264204
P28033 (Cebpb) S184 PhosphoSitePlus 17601773, 17264204
P28033 (Cebpb) T188 PhosphoSitePlus   Signor 15367685, 22355693
P40338 (Vhl) S34 PhosphoSitePlus 16847331
P49769 (Psen1) S353 RLIMS-P+ 17360711
P49769 (Psen1) S357 RLIMS-P+ 17360711
P70447 (Neurog2) S231 PhosphoSitePlus 18400164
P70447 (Neurog2) S234 PhosphoSitePlus 18400164
P97287 (Mcl1) S140 Signor 16543145
Q02248 (Ctnnb1) S29 PhosphoSitePlus 9233789
Q02248 (Ctnnb1) S33 PhosphoSitePlus 9233789, 12417018
Q02248 (Ctnnb1) S37 PhosphoSitePlus 9233789, 12417018
Q02248 (Ctnnb1) T41 PhosphoSitePlus 9233789
Q02248 (Ctnnb1) S45 PhosphoSitePlus 9233789
Q3TFD2 (Lpcat1) S178 PhosphoSitePlus 21068446
Q3TFD2 (Lpcat1) S182 PhosphoSitePlus 21068446
Q60795 (Nfe2l2) S335 PhosphoSitePlus 21245377
Q60795 (Nfe2l2) S338 PhosphoSitePlus 21245377
Q60795 (Nfe2l2) S342 PhosphoSitePlus 21245377
Q60795 (Nfe2l2) S347 PhosphoSitePlus 21245377
Q60795 (Nfe2l2) S351 PhosphoSitePlus 21245377
Q60795 (Nfe2l2) S355 PhosphoSitePlus 21245377
Q62188 (Dpysl3) T509 PhosphoSitePlus 16611631
Q8BMD2 (Dzip1) S520 PhosphoSitePlus 25860027
Q8BUV3 (Gphn) S270 PhosphoSitePlus 21173228
Q9DBD5 (Pelp1) T751 PhosphoSitePlus 26627258
Q9JHG6 (Rcan1) S112 PhosphoSitePlus 12063245
Q9R194 (Cry2) S553 PhosphoSitePlus 15980066, 20123978
Q9R194 (Cry2) S557 PhosphoSitePlus 15980066


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046095 (mGSK3B/Phos:1) pS9 PRO 16522636, 26582204


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035654 (mDISC1/iso:1/PhosRes-) Interaction PR:Q9WV60 (mGSK3B) PRO 21471969
PR:000037187 (mCTNNB1/Phos:2) increased Interaction PR:Q9WV60 (mGSK3B) PRO 12432063