iPTMnet Report for Q9UQQ2 (SH2B3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UQQ2 / SH2B3_HUMAN
Protein Name SH2B adapter protein 3
Gene Name Name: SH2B3
Synonyms:LNK;
Organism Homo sapiens (Human)

PRO ID PR:Q9UQQ2
DAG View
PRO Name SH2B adapter protein 3 (human)
Definition An SH2B adapter protein 3 that is encoded in the genome of human.
Short Label hSH2B3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UQQ2 (SH2B3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus   UniProt 23186163
S120 Phosphorylation PhosphoSitePlus   UniProt 23186163
S150 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163
T159 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
Y203 Phosphorylation PhosphoSitePlus
Y273 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   Signor 9169414
Y273 Phosphorylation P06239 (LCK) HPRD   phospho.ELM   Signor 9169414
Y273 Phosphorylation P43403 (ZAP70) HPRD   phospho.ELM   Signor 9169414
S330 Phosphorylation PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
Y555 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
Y572 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 L10 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y273 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S337 P337 Biomuta DOID:9256 / colorectal cancer [ cosmic ]