iPTMnet Report for Q9UQE7 (SMC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UQE7 / SMC3_HUMAN
Protein Name Structural maintenance of chromosomes protein 3
Gene Name Name: SMC3
Synonyms:BAM,BMH,CSPG6,SMC3L1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UQE7
DAG View
PRO Name structural maintenance of chromosomes protein 3 (human)
Definition A structural maintenance of chromosomes protein 3 that is encoded in the genome of human.
Short Label hSMC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UQE7 (SMC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T18 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
R72 Methylation PhosphoSitePlus
S85 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K105 Acetylation PRO   PhosphoSitePlus   UniProt 19907496, 19608861, 18614053
K106 Acetylation PRO   PhosphoSitePlus   UniProt 19907496, 19608861, 18614053
K106 Ubiquitination PhosphoSitePlus
Y109 Phosphorylation PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Sumoylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
K140 Acetylation PhosphoSitePlus   UniProt 19608861
K140 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
R155 Methylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
S175 Phosphorylation HPRD   PhosphoSitePlus 20068231
S177 Phosphorylation HPRD   PhosphoSitePlus 20068231
K180 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
R236 Methylation PhosphoSitePlus
K238 Acetylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
S243 Phosphorylation HPRD   PhosphoSitePlus 20068231
K245 Methylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
R272 Methylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
R323 Methylation PhosphoSitePlus
K336 Acetylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
T386 O-Glycosylation GlyGen 33214551, 34725712, 29351928, ...34019948, 28510447, 34229054
S387 O-Glycosylation GlyGen 33214551, 34725712, 29351928, ...34019948, 28510447, 34229054
S387 Phosphorylation PhosphoSitePlus
K409 Methylation PhosphoSitePlus
K427 Methylation PhosphoSitePlus
K429 Methylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K445 Methylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
R453 Methylation PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K486 Methylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
Y560 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
Y600 Phosphorylation PhosphoSitePlus
K612 Ubiquitination PhosphoSitePlus
Y615 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
S639 Phosphorylation PhosphoSitePlus
R644 Methylation PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
Y669 Phosphorylation PhosphoSitePlus
S674 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
S731 Phosphorylation HPRD   PhosphoSitePlus 20068231
S737 Phosphorylation HPRD   PhosphoSitePlus 20068231
T773 Phosphorylation PhosphoSitePlus
T783 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S787 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 20068231
S790 Phosphorylation PhosphoSitePlus
K795 Acetylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
K820 Acetylation PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
R851 Methylation PhosphoSitePlus
K871 Ubiquitination PhosphoSitePlus
S886 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18452278
K889 Ubiquitination PhosphoSitePlus
T926 Phosphorylation PhosphoSitePlus
K956 Acetylation PhosphoSitePlus
K956 Ubiquitination PhosphoSitePlus
K963 Ubiquitination PhosphoSitePlus
K968 Acetylation PhosphoSitePlus
K968 Ubiquitination PhosphoSitePlus
K977 Ubiquitination PhosphoSitePlus
K985 Ubiquitination PhosphoSitePlus
K997 Methylation PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
K1002 Ubiquitination PhosphoSitePlus
R1009 Methylation PhosphoSitePlus
K1012 Ubiquitination PhosphoSitePlus
S1013 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1025 Ubiquitination PhosphoSitePlus
K1034 Ubiquitination PhosphoSitePlus
K1038 Ubiquitination PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
K1059 Ubiquitination PhosphoSitePlus
S1065 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 18077418, 15302935, ...18669648, 24275569
S1067 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 23186163, 18077418, ...15302935, 21406692, 22067460, 18669648, 24275569, 18442975, 20068231
S1074 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18077418, 15302935
S1077 Phosphorylation PhosphoSitePlus
R1079 Methylation PhosphoSitePlus
S1081 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S1083 Phosphorylation Q13315 (ATM) HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 19629043, 22346761, ...15302935, 21406692, 20501661, 18669648, 18442975, 20068231
S1085 Phosphorylation PhosphoSitePlus
S1086 Phosphorylation PhosphoSitePlus
K1105 Ubiquitination PhosphoSitePlus
S1116 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1190 Acetylation PhosphoSitePlus   UniProt 19608861
K1190 Ubiquitination PhosphoSitePlus
K1194 Ubiquitination PhosphoSitePlus
K1207 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049293 (hSMC3/Ac:1) acK105,acK106 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R72 C72 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S85 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S177 F177 Biomuta DOID:4159 / skin cancer [ cosmic ]
K180 N180 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y213 C213 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R236 H236 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R236 C236 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S243 Y243 Biomuta DOID:363 / uterine cancer [ icgc ]
S243 C243 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K427 E427 Biomuta DOID:263 / kidney cancer [ cosmic ]
S639 L639 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R644 S644 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y669 H669 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y669 D669 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S731 A731 Biomuta DOID:263 / kidney cancer [ cosmic ]
S731 C731 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K795 N795 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R851 T851 Biomuta DOID:1324 / lung cancer [ cosmic ]
K985 T985 Biomuta DOID:3571 / liver cancer [ cosmic ]
K985 E985 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R1009 S1009 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1012 R1012 Biomuta DOID:363 / uterine cancer [ icgc ]
S1013 L1013 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K1046 E1046 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1065 I1065 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1077 R1077 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R1079 G1079 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1081 Y1081 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S1116 L1116 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]