iPTMnet Report for Q9UQ88 (CDK11A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UQ88 / CD11A_HUMAN
Protein Name Cyclin-dependent kinase 11A
Gene Name Name: CDK11A
Synonyms:CDC2L2,CDC2L3,PITSLREB;
Organism Homo sapiens (Human)

PRO ID PR:Q9UQ88
DAG View
PRO Name cyclin-dependent kinase 11A (human)
Definition A cyclin-dependent kinase 11A that is encoded in the genome of human.
Short Label hCDK11A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UQ88 (CDK11A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Sumoylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K20 Sumoylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K29 Sumoylation PhosphoSitePlus
S47 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T61 Phosphorylation PhosphoSitePlus
S65 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y67 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K254 Sumoylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
S271 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935, 18220336
S273 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S346 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
K407 Sumoylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
T436 Phosphorylation PhosphoSitePlus
Y437 Phosphorylation PhosphoSitePlus
Y441 Phosphorylation PhosphoSitePlus
K444 Acetylation PhosphoSitePlus
K446 Acetylation PhosphoSitePlus
K447 Acetylation PhosphoSitePlus
K447 Sumoylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K455 Sumoylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
K479 Sumoylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
K552 Sumoylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
Y575 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
T583 Phosphorylation PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
K637 Sumoylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
K640 Ubiquitination PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
K661 Sumoylation PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
T663 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
K707 Sumoylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
T714 Phosphorylation PhosphoSitePlus
K729 Sumoylation PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
T739 Phosphorylation PhosphoSitePlus
S740 Phosphorylation neXtProt   PhosphoSitePlus 23178491
S740 Phosphorylation O96017 (CHEK2) neXtProt 23178491
Y750 Phosphorylation PhosphoSitePlus
S751 Phosphorylation PhosphoSitePlus
T761 Phosphorylation PhosphoSitePlus
T766 Phosphorylation PhosphoSitePlus
S773 Phosphorylation PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
K782 Methylation PhosphoSitePlus
K782 Sumoylation PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T370 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 19651622, 18669648
S65 Phosphorylation HPRD 18669648
S92 Phosphorylation HPRD 17081983
S232 Phosphorylation HPRD 17081983
K251 Sumoylation PhosphoSitePlus
S262 Phosphorylation HPRD 19651622
S268 Phosphorylation HPRD 19651622, 18669648, 17081983
S270 Phosphorylation HPRD 19651622, 18669648, 17081983
S574 Phosphorylation HPRD 18669648
Y579 Phosphorylation HPRD 19651622, 18669648
T580 Phosphorylation HPRD 17322306, 19651622, 18669648
T736 Phosphorylation HPRD 19651622, 18669648, 17081983
S737 Phosphorylation HPRD 19651622, 18669648, 17081983
S748 Phosphorylation HPRD 19651622
T758 Phosphorylation HPRD 18669648
T763 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 19651622, 18669648
S65 Phosphorylation HPRD 18669648
S92 Phosphorylation HPRD 17081983
S222 Phosphorylation HPRD 17081983
S252 Phosphorylation HPRD 19651622
S258 Phosphorylation HPRD 19651622, 18669648, 17081983
S260 Phosphorylation HPRD 19651622, 18669648, 17081983
S564 Phosphorylation HPRD 18669648
Y569 Phosphorylation HPRD 19651622, 18669648
T570 Phosphorylation HPRD 17322306, 19651622, 18669648
T726 Phosphorylation HPRD 19651622, 18669648, 17081983
S727 Phosphorylation HPRD 19651622, 18669648, 17081983
S738 Phosphorylation HPRD 19651622
T748 Phosphorylation HPRD 18669648
T753 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
K18 Acetylation PhosphoSitePlus


Q9UQ88 (CDK11A) as PTM Enzyme



Substrate Site Score Source PMID
O95238 (SPDEF) S238 PhosphoSitePlus 26885618
O95238 (SPDEF) S242 PhosphoSitePlus 26885618
O95238 (SPDEF) S243 PhosphoSitePlus 26885618
P21127-12 (CDK11B) T370 PhosphoSitePlus 21078675
P21127 (CDK11B) T726 Signor 21078675


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y437 C437 Biomuta DOID:3571 / liver cancer [ icgc ]
K539 E539 Biomuta DOID:5041 / esophageal cancer [ tcga ]
Y582 H582 Biomuta DOID:10534 / stomach cancer [ icgc ]
K661 R661 Biomuta DOID:1909 / melanoma [ cosmic ]