iPTMnet Report for Q9UQ88 (CDK11A)
Protein Information
UniProt AC / UniProt ID | Q9UQ88 / CD11A_HUMAN |
Protein Name | Cyclin-dependent kinase 11A |
Gene Name | Name: CDK11A Synonyms:CDC2L2,CDC2L3,PITSLREB; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9UQ88 |
PRO Name | cyclin-dependent kinase 11A (human) |
Definition | A cyclin-dependent kinase 11A that is encoded in the genome of human. |
Short Label | hCDK11A |
Category | organism-gene |
Q9UQ88 (CDK11A) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K11 | Sumoylation | score1 | PhosphoSitePlus | |||
K11 | Ubiquitination | score1 | PhosphoSitePlus | |||
K20 | Sumoylation | score1 | PhosphoSitePlus | |||
K20 | Ubiquitination | score1 | PhosphoSitePlus | |||
K29 | Sumoylation | score1 | PhosphoSitePlus | |||
S47 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
T61 | Phosphorylation | score1 | PhosphoSitePlus | |||
S65 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
Y67 | Phosphorylation | score1 | PhosphoSitePlus | |||
S72 | Phosphorylation | score1 | PhosphoSitePlus | |||
K101 | Acetylation | score1 | PhosphoSitePlus | |||
K123 | Acetylation | score1 | PhosphoSitePlus | |||
S200 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y210 | Phosphorylation | score1 | PhosphoSitePlus | |||
S211 | Phosphorylation | score1 | PhosphoSitePlus | |||
K213 | Acetylation | score1 | PhosphoSitePlus | |||
S217 | Phosphorylation | score1 | PhosphoSitePlus | |||
S220 | Phosphorylation | score1 | PhosphoSitePlus | |||
S222 | Phosphorylation | score1 | PhosphoSitePlus | |||
K254 | Sumoylation | score1 | PhosphoSitePlus | |||
S265 | Phosphorylation | score1 | PhosphoSitePlus | |||
S271 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648, 15302935, 18220336 | ||
S273 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S346 | Phosphorylation | score1 | PhosphoSitePlus | |||
S369 | Phosphorylation | score1 | PhosphoSitePlus | |||
S372 | Phosphorylation | score1 | PhosphoSitePlus | |||
S398 | Phosphorylation | score1 | PhosphoSitePlus | |||
K407 | Sumoylation | score1 | PhosphoSitePlus | |||
K412 | Ubiquitination | score1 | PhosphoSitePlus | |||
S422 | Phosphorylation | score1 | PhosphoSitePlus | |||
T436 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y437 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y441 | Phosphorylation | score1 | PhosphoSitePlus | |||
K444 | Acetylation | score1 | PhosphoSitePlus | |||
K446 | Acetylation | score1 | PhosphoSitePlus | |||
K447 | Acetylation | score1 | PhosphoSitePlus | |||
K447 | Sumoylation | score1 | PhosphoSitePlus | |||
K447 | Ubiquitination | score1 | PhosphoSitePlus | |||
K455 | Acetylation | score1 | PhosphoSitePlus | |||
K455 | Sumoylation | score1 | PhosphoSitePlus | |||
K455 | Ubiquitination | score1 | PhosphoSitePlus | |||
K463 | Ubiquitination | score1 | PhosphoSitePlus | |||
K479 | Sumoylation | score1 | PhosphoSitePlus | |||
K479 | Ubiquitination | score1 | PhosphoSitePlus | |||
K519 | Ubiquitination | score1 | PhosphoSitePlus | |||
K539 | Ubiquitination | score1 | PhosphoSitePlus | |||
K552 | Sumoylation | score1 | PhosphoSitePlus | |||
K552 | Ubiquitination | score1 | PhosphoSitePlus | |||
K565 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y575 | Phosphorylation | score1 | PhosphoSitePlus | |||
S577 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y582 | Phosphorylation | score1 | PhosphoSitePlus | |||
T583 | Phosphorylation | score1 | PhosphoSitePlus | |||
T588 | Phosphorylation | score1 | PhosphoSitePlus | |||
K637 | Sumoylation | score1 | PhosphoSitePlus | |||
K637 | Ubiquitination | score1 | PhosphoSitePlus | |||
K640 | Ubiquitination | score1 | PhosphoSitePlus | |||
K648 | Ubiquitination | score1 | PhosphoSitePlus | |||
K660 | Ubiquitination | score1 | PhosphoSitePlus | |||
K661 | Sumoylation | score1 | PhosphoSitePlus | |||
K661 | Ubiquitination | score1 | PhosphoSitePlus | |||
T663 | Phosphorylation | score1 | PhosphoSitePlus | |||
S701 | Phosphorylation | score1 | PhosphoSitePlus | |||
K707 | Sumoylation | score1 | PhosphoSitePlus | |||
K707 | Ubiquitination | score1 | PhosphoSitePlus | |||
T714 | Phosphorylation | score1 | PhosphoSitePlus | |||
K729 | Sumoylation | score1 | PhosphoSitePlus | |||
K729 | Ubiquitination | score1 | PhosphoSitePlus | |||
T739 | Phosphorylation | score1 | PhosphoSitePlus | |||
S740 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 23178491 | ||
S740 | Phosphorylation | O96017 (CHEK2) | score2 | neXtProt | 23178491 | |
Y750 | Phosphorylation | score1 | PhosphoSitePlus | |||
S751 | Phosphorylation | score1 | PhosphoSitePlus | |||
T761 | Phosphorylation | score1 | PhosphoSitePlus | |||
T766 | Phosphorylation | score1 | PhosphoSitePlus | |||
S773 | Phosphorylation | score1 | PhosphoSitePlus | |||
S780 | Phosphorylation | score1 | PhosphoSitePlus | |||
K782 | Methylation | score1 | PhosphoSitePlus | |||
K782 | Sumoylation | score1 | PhosphoSitePlus | |||
K782 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T370 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S47 | Phosphorylation | score0 | HPRD | 19651622, 18669648 | ||
S65 | Phosphorylation | score0 | HPRD | 18669648 | ||
S92 | Phosphorylation | score0 | HPRD | 17081983 | ||
S232 | Phosphorylation | score0 | HPRD | 17081983 | ||
K251 | Sumoylation | score1 | PhosphoSitePlus | |||
S262 | Phosphorylation | score0 | HPRD | 19651622 | ||
S268 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983 | ||
S270 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983 | ||
S574 | Phosphorylation | score0 | HPRD | 18669648 | ||
Y579 | Phosphorylation | score0 | HPRD | 19651622, 18669648 | ||
T580 | Phosphorylation | score0 | HPRD | 17322306, 19651622, 18669648 | ||
T736 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983 | ||
S737 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983 | ||
S748 | Phosphorylation | score0 | HPRD | 19651622 | ||
T758 | Phosphorylation | score0 | HPRD | 18669648 | ||
T763 | Phosphorylation | score0 | HPRD | 18669648 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S47 | Phosphorylation | score0 | HPRD | 19651622, 18669648 | ||
S65 | Phosphorylation | score0 | HPRD | 18669648 | ||
S92 | Phosphorylation | score0 | HPRD | 17081983 | ||
S222 | Phosphorylation | score0 | HPRD | 17081983 | ||
S252 | Phosphorylation | score0 | HPRD | 19651622 | ||
S258 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983 | ||
S260 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983 | ||
S564 | Phosphorylation | score0 | HPRD | 18669648 | ||
Y569 | Phosphorylation | score0 | HPRD | 19651622, 18669648 | ||
T570 | Phosphorylation | score0 | HPRD | 17322306, 19651622, 18669648 | ||
T726 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983 | ||
S727 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 17081983 | ||
S738 | Phosphorylation | score0 | HPRD | 19651622 | ||
T748 | Phosphorylation | score0 | HPRD | 18669648 | ||
T753 | Phosphorylation | score0 | HPRD | 18669648 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K18 | Acetylation | score1 | PhosphoSitePlus |
Q9UQ88 (CDK11A) as PTM Enzyme
Substrate | Site | Score | Source | PMID | |
---|---|---|---|---|---|
O95238 (SPDEF) | S238 | score2 | PhosphoSitePlus | 26885618 | |
O95238 (SPDEF) | S242 | score2 | PhosphoSitePlus | 26885618 | |
O95238 (SPDEF) | S243 | score2 | PhosphoSitePlus | 26885618 | |
P21127-12 (CDK11B) | T370 | score2 | PhosphoSitePlus | 21078675 | |
P21127 (CDK11B) | T726 | score1 | Signor | 21078675 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y437 | C437 | Biomuta | DOID:3571 / liver cancer [ icgc ] | |
K539 | E539 | Biomuta | DOID:5041 / esophageal cancer [ tcga ] | |
Y582 | H582 | Biomuta | DOID:10534 / stomach cancer [ icgc ] | |
K661 | R661 | Biomuta | DOID:1909 / melanoma [ cosmic ] |