Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UQ84 / EXO1_HUMAN
Protein Name Exonuclease 1
Gene Name Name: EXO1
Synonyms:EXOI,HEX1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UQ84
DAG View
PRO Name exonuclease 1 (human)
Definition An exonuclease 1 that is encoded in the genome of human.
Short Label hEXO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UQ84 (EXO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S68 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18048416
K391 Ubiquitination PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S422 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18048416
S454 Phosphorylation PhosphoSitePlus   UniProt 18048416
T475 Phosphorylation PhosphoSitePlus
T479 Phosphorylation PhosphoSitePlus
K482 Acetylation PhosphoSitePlus   UniProt 18048416
K482 Sumoylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
T502 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
T581 Phosphorylation PhosphoSitePlus   UniProt 18048416
S598 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15302935, 23186163, 18048416, ...18220336
S610 Phosphorylation PhosphoSitePlus   UniProt 23186163
T621 Phosphorylation PhosphoSitePlus   UniProt 18048416
S623 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18048416
S639 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18048416
S659 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus   UniProt 18048416
S674 Phosphorylation PhosphoSitePlus   UniProt 18048416
S700 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
S714 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17525332, 20019063, 18048416
T732 Phosphorylation PhosphoSitePlus
K743 Methylation PhosphoSitePlus
S746 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18048416, 31053472
S749 Phosphorylation PhosphoSitePlus
T752 Phosphorylation PhosphoSitePlus
K784 Sumoylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
T824 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K214 T214 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S353 R353 Biomuta DOID:363 / uterine cancer [ tcga ]
S415 F415 Biomuta DOID:363 / uterine cancer [ tcga ]
T479 M479 Biomuta DOID:10534 / stomach cancer [ tcga ]
S494 T494 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S510 L510 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S512 Y512 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T621 M621 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S660 C660 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S700 F700 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K784 N784 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K796 T796 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]