iPTMnet Report for Q9UPZ9 (CILK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPZ9 / CILK1_HUMAN
Protein Name Serine/threonine-protein kinase ICK
Gene Name Name: CILK1
Synonyms:ICK,KIAA0936;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPZ9
DAG View
PRO Name serine/threonine-protein kinase ICK (human)
Definition A serine/threonine-protein kinase ICK that is encoded in the genome of human.
Short Label hCILK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPZ9 (CILK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
Y15 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
Y156 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T157 Phosphorylation P50613 (CDK7) , Q8IZL9 (CDK20) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16954377, 10699974, 15988018
Y159 Phosphorylation Q9UPZ9 (CILK1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18083107, 10699974, 15988018
Y177 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
S254 Phosphorylation PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
T478 Phosphorylation PhosphoSitePlus
K491 Methylation PhosphoSitePlus
Y495 Phosphorylation RLIMS-P 30782830
S520 Phosphorylation PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus
Y555 Phosphorylation RLIMS-P 30782830
K562 Acetylation PhosphoSitePlus
Y583 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y156 Phosphorylation HPRD 18083107, 18691976
T157 Phosphorylation HPRD 10699974
Y159 Phosphorylation HPRD 18691976, 10699974
S254 Phosphorylation HPRD 20068231


Q9UPZ9 (CILK1) as PTM Enzyme



Substrate Site Score Source PMID
P46379 (BAG6) T1080 PhosphoSitePlus 16954377
Q8N122 (RPTOR) T908 PhosphoSitePlus   Signor 22356909
Q9UPZ9 (CILK1) Y159 Signor 15988018


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T6 A6 Biomuta DOID:363 / uterine cancer [ icgc ]
T14 A14 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y15 F15 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y15 H15 Biomuta DOID:1612 / breast cancer [ cosmic ]
S23 N23 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S254 T254 Biomuta DOID:1324 / lung cancer [ cosmic ]
T478 M478 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S528 F528 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]