iPTMnet Report for Q9UPY3 (DICER1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPY3 / DICER_HUMAN
Protein Name Endoribonuclease Dicer
Gene Name Name: DICER1
Synonyms:DICER,HERNA,KIAA0928;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPY3
DAG View
PRO Name endoribonuclease Dicer (human)
Definition An endoribonuclease Dicer that is encoded in the genome of human.
Short Label hDICER1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPY3 (DICER1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation PhosphoSitePlus
C152 Methylation IEDB 31844290
T238 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus   UniProt 21406692
S415 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y452 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
K652 Ubiquitination PhosphoSitePlus
Y664 Phosphorylation PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
Y819 Phosphorylation PhosphoSitePlus
T820 Phosphorylation PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
T967 Phosphorylation PhosphoSitePlus
T1001 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28642363, 18669648, 35995401, ...29394246
K1023 Ubiquitination PhosphoSitePlus
Y1091 Phosphorylation PhosphoSitePlus
Y1121 Phosphorylation PhosphoSitePlus
C1122 S-Nitrosylation dbSNO 26338901
S1142 Phosphorylation PhosphoSitePlus
S1160 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1204 Phosphorylation PhosphoSitePlus
S1252 Phosphorylation PhosphoSitePlus
S1255 Phosphorylation PhosphoSitePlus
S1280 Phosphorylation PhosphoSitePlus
T1329 Phosphorylation PhosphoSitePlus
Y1330 Phosphorylation PhosphoSitePlus
K1350 Ubiquitination PhosphoSitePlus
K1391 Acetylation PhosphoSitePlus
K1433 Ubiquitination PhosphoSitePlus
Y1438 Phosphorylation PhosphoSitePlus
Y1445 Phosphorylation PhosphoSitePlus
S1460 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1465 Ubiquitination PhosphoSitePlus
K1466 Ubiquitination PhosphoSitePlus
S1468 Phosphorylation PhosphoSitePlus
S1470 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1479 Phosphorylation PhosphoSitePlus
K1595 Ubiquitination PhosphoSitePlus
S1612 Phosphorylation PhosphoSitePlus
K1615 Ubiquitination PhosphoSitePlus
C1700 Methylation IEDB 31844290
S1728 Phosphorylation PhosphoSitePlus   RLIMS-P 28642363
S1852 Phosphorylation PhosphoSitePlus   RLIMS-P 28642363
S1868 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1922 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y664 Phosphorylation HPRD 15592455
S1016 Phosphorylation HPRD 19413330, 18669648
S1160 Phosphorylation HPRD 19664994
S1255 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9UKV8 (AGO2) Y393 Q9UPY3 (DICER1) decreased_association eFIP 31981897


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S82 P82 Biomuta DOID:363 / uterine cancer [ cosmic ]
S413 G413 Biomuta DOID:363 / uterine cancer [ icgc ]
Y452 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S643 I643 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y668 D668 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T820 I820 Biomuta DOID:1324 / lung cancer [ cosmic ]
S828 F828 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S962 F962 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1142 F1142 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1160 F1160 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1160 Y1160 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S1252 P1252 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1280 N1280 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1280 I1280 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y1330 H1330 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K1391 N1391 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1433 M1433 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K1615 N1615 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1728 F1728 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]