Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPX8 / SHAN2_HUMAN
Protein Name SH3 and multiple ankyrin repeat domains protein 2
Gene Name Name: SHANK2
Synonyms:CORTBP1,KIAA1022,PROSAP1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPX8
DAG View
PRO Name SH3 and multiple ankyrin repeat domains protein 2 (human)
Definition An SH3 and multiple ankyrin repeat domains protein 2 that is encoded in the genome of human.
Short Label hSHANK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPX8 (SHANK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S65 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
T341 Phosphorylation PhosphoSitePlus
T349 Phosphorylation PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
Y437 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
Y538 Phosphorylation PhosphoSitePlus
S549 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
T561 Phosphorylation PhosphoSitePlus
T564 Phosphorylation PhosphoSitePlus
Y580 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation PhosphoSitePlus
Y610 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus
Y622 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
T662 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
T726 Phosphorylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
Y822 Phosphorylation PhosphoSitePlus
T827 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
Y869 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
T890 Phosphorylation PhosphoSitePlus
T899 Phosphorylation PhosphoSitePlus
Y903 Phosphorylation PhosphoSitePlus
S931 Phosphorylation PhosphoSitePlus
T939 Phosphorylation PhosphoSitePlus
T943 Phosphorylation PhosphoSitePlus
S1001 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus
S1071 Phosphorylation PhosphoSitePlus
S1080 Phosphorylation PhosphoSitePlus
S1103 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus
S1282 Phosphorylation PhosphoSitePlus
S1330 Phosphorylation PhosphoSitePlus
S1334 Phosphorylation PhosphoSitePlus
S1382 Phosphorylation PhosphoSitePlus
S1384 Phosphorylation PhosphoSitePlus
S1386 Phosphorylation PhosphoSitePlus
S1395 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation HPRD 18452278
S1648 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
Y372 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
T683 Phosphorylation PhosphoSitePlus
S853 Phosphorylation PhosphoSitePlus
S1053 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y144 C144 Biomuta DOID:1909 / melanoma [ cosmic ]
T339 M339 Biomuta DOID:4362 / cervical cancer [ tcga ]
T349 N349 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T349 A349 Biomuta DOID:363 / uterine cancer [ tcga ]
T367 A367 Biomuta DOID:363 / uterine cancer [ tcga ]
S372 F372 Biomuta DOID:1909 / melanoma [ icgc ]
Y437 * Biomuta DOID:3571 / liver cancer [ icgc ]
S452 G452 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S470 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S581 F581 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y588 F588 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S611 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y622 H622 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y622 N622 Biomuta DOID:1324 / lung cancer [ cosmic ]
S643 R643 Biomuta DOID:3571 / liver cancer [ icgc ]
S643 I643 Biomuta DOID:1324 / lung cancer [ cosmic ]
S665 R665 Biomuta DOID:3571 / liver cancer [ icgc ]
S720 F720 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T899 K899 Biomuta DOID:3571 / liver cancer [ icgc ]
T899 M899 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S931 L931 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]
T939 A939 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T943 S943 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S1001 F1001 Biomuta DOID:363 / uterine cancer [ tcga ]
S1071 L1071 Biomuta DOID:363 / uterine cancer [ tcga ]
S1080 Y1080 Biomuta DOID:3070 / malignant glioma [ tcga ]
S1269 L1269 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1334 L1334 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S1334 P1334 Biomuta DOID:363 / uterine cancer [ tcga ]
S1384 L1384 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S1386 P1386 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1395 L1395 Biomuta DOID:1909 / melanoma [ icgc, tcga ]