iPTMnet Report for Q9UPU5 (USP24)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPU5 / UBP24_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 24
Gene Name Name: USP24
Synonyms:KIAA1057;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPU5
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 24 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 24 that is encoded in the genome of human.
Short Label hUSP24
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPU5 (USP24) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K31 Ubiquitination PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
S58 Phosphorylation HPRD   PhosphoSitePlus 18669648
S63 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 18220336
S84 Phosphorylation PhosphoSitePlus
R85 Methylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus   UniProt 24275569
K145 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
T198 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y205 Phosphorylation HPRD   PhosphoSitePlus 20068231
S251 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
T673 Phosphorylation PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
Y814 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus
T901 Phosphorylation PhosphoSitePlus
S914 Phosphorylation PhosphoSitePlus
Y916 Phosphorylation PhosphoSitePlus
K1017 Ubiquitination PhosphoSitePlus
T1039 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation HPRD   PhosphoSitePlus 18669648
S1060 Phosphorylation PhosphoSitePlus
Y1063 Phosphorylation PhosphoSitePlus
K1128 Ubiquitination PhosphoSitePlus
S1132 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
S1136 Phosphorylation PhosphoSitePlus
S1138 Phosphorylation PhosphoSitePlus
S1139 Phosphorylation PhosphoSitePlus
K1140 Ubiquitination PhosphoSitePlus
S1141 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1143 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
T1280 Phosphorylation PhosphoSitePlus
S1281 Phosphorylation PhosphoSitePlus
S1285 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1289 Phosphorylation PhosphoSitePlus
K1292 Ubiquitination PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus
S1305 Phosphorylation PhosphoSitePlus
T1321 Phosphorylation PhosphoSitePlus
S1329 Phosphorylation PhosphoSitePlus
T1330 Phosphorylation PhosphoSitePlus
K1356 Ubiquitination PhosphoSitePlus
S1360 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
S1372 Phosphorylation PhosphoSitePlus
S1373 Phosphorylation PhosphoSitePlus
S1375 Phosphorylation PhosphoSitePlus
S1378 Phosphorylation PhosphoSitePlus
S1379 Phosphorylation PhosphoSitePlus
S1381 Phosphorylation PhosphoSitePlus
T1575 Phosphorylation PhosphoSitePlus
S1578 Phosphorylation PhosphoSitePlus
S1610 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S1612 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S1616 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 20068231, 17081983, 27991932
S1620 Phosphorylation HPRD   PhosphoSitePlus 17525332
K1627 Ubiquitination PhosphoSitePlus
K1764 Ubiquitination PhosphoSitePlus
S1854 Phosphorylation PhosphoSitePlus
Y1857 Phosphorylation PhosphoSitePlus
K1899 Ubiquitination PhosphoSitePlus
S1935 Phosphorylation PhosphoSitePlus
S1943 Phosphorylation HPRD   IEDB   PhosphoSitePlus 19651622, 32387766, 20068231
Y2018 Phosphorylation PhosphoSitePlus
Y2024 Phosphorylation PhosphoSitePlus
T2025 Phosphorylation PhosphoSitePlus
S2043 Phosphorylation HPRD 20068231
S2047 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 16964243, 18707149, 18691976, ...21406692, 23186163, 24275569, 19413330, 18088087, 18767875, 20058876, 19007248, 15144186, 19651622, 27991932, 19369195, 19664994, 19664995, 17322306, 18669648, 20166139, 19415658, 20068231
S2057 Phosphorylation PhosphoSitePlus
S2077 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231
S2080 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S2081 Phosphorylation HPRD   PhosphoSitePlus 18669648
K2097 Ubiquitination PhosphoSitePlus
K2105 Ubiquitination PhosphoSitePlus
Y2117 Phosphorylation PhosphoSitePlus
Y2134 Phosphorylation PhosphoSitePlus
Y2138 Phosphorylation PhosphoSitePlus
Y2157 Phosphorylation PhosphoSitePlus
Y2158 Phosphorylation PhosphoSitePlus
K2294 Sumoylation PhosphoSitePlus
S2307 Phosphorylation PhosphoSitePlus
S2330 Phosphorylation PhosphoSitePlus
Y2497 Phosphorylation PhosphoSitePlus
S2536 Phosphorylation PhosphoSitePlus
Y2539 Phosphorylation PhosphoSitePlus
T2541 Phosphorylation PhosphoSitePlus
K2554 Ubiquitination PhosphoSitePlus
T2559 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231, 18691976
S2561 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20058876, ...17322306, 18669648, 19690332, 20068231
T2565 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 20058876, 19651622, ...18669648, 20068231
Y2568 Phosphorylation PhosphoSitePlus
T2570 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S2587 Phosphorylation HPRD 20068231
S2588 Phosphorylation PhosphoSitePlus
S2602 Phosphorylation PhosphoSitePlus
S2604 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 23186163, 27991932, ...18669648, 20068231
S2613 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y205 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y205 C205 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K603 E603 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K664 N664 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
T673 M673 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
Y814 S814 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K1017 M1017 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K1017 N1017 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1041 Y1041 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1136 F1136 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1141 T1141 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S1143 F1143 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1299 F1299 Biomuta [ cosmic ]
S1360 F1360 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1578 A1578 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1578 L1578 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K1764 T1764 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1854 I1854 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1943 F1943 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2047 F2047 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S2077 L2077 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y2117 * Biomuta DOID:263 / kidney cancer [ cosmic ]
Y2157 * Biomuta DOID:363 / uterine cancer [ cosmic ]
Y2497 C2497 Biomuta DOID:1324 / lung cancer [ cosmic ]
T2565 M2565 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T2565 K2565 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2588 G2588 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2602 L2602 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2613 N2613 Biomuta DOID:10534 / stomach cancer [ cosmic ]