iPTMnet Report for Q9UPT9 (USP22)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPT9 / UBP22_HUMAN
Protein Name Ubiquitin carboxyl-terminal hydrolase 22
Gene Name Name: USP22
Synonyms:KIAA1063,USP3L;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPT9
DAG View
PRO Name ubiquitin carboxyl-terminal hydrolase 22 (human)
Definition A ubiquitin carboxyl-terminal hydrolase 22 that is encoded in the genome of human.
Short Label hUSP22
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPT9 (USP22) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C23 Methylation IEDB 31844290
K35 Ubiquitination PhosphoSitePlus
C44 Methylation IEDB 31844290
K59 Ubiquitination PhosphoSitePlus
C66 Methylation IEDB 31844290
K95 Ubiquitination PhosphoSitePlus
K129 Acetylation PhosphoSitePlus   UniProt 19608861
K129 Sumoylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K137 Sumoylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus   RLIMS-P 27030811
T151 Phosphorylation PhosphoSitePlus
K152 Sumoylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
R208 Methylation PhosphoSitePlus
Y232 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus   RLIMS-P 27030811
C311 Methylation IEDB 31844290
K380 Ubiquitination PhosphoSitePlus
K382 Sumoylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K417 Acetylation PhosphoSitePlus
K417 Sumoylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
T423 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
Y450 Phosphorylation PhosphoSitePlus
K462 Sumoylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
R485 Methylation PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S237 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K35 E35 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K59 N59 Biomuta DOID:363 / uterine cancer [ cosmic ]
K129 N129 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
K144 R144 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S146 L146 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K152 I152 Biomuta DOID:3571 / liver cancer [ cosmic ]
K152 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K159 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
R208 K208 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K410 R410 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R485 W485 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]