iPTMnet Report for Q9UPS6 (SETD1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPS6 / SET1B_HUMAN
Protein Name Histone-lysine N-methyltransferase SETD1B
Gene Name Name: SETD1B
Synonyms:KIAA1076,KMT2G,SET1B;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPS6
DAG View
PRO Name histone-lysine N-methyltransferase SETD1B (human)
Definition A histone-lysine N-methyltransferase SETD1B that is encoded in the genome of human.
Short Label hSETD1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPS6 (SETD1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K41 Methylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
Y126 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
R278 Methylation PhosphoSitePlus
S284 O-Glycosylation GlyGen 30620550
S291 Phosphorylation PhosphoSitePlus
R292 Methylation PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
K309 Methylation PhosphoSitePlus
S333 Phosphorylation IEDB 32357974
T360 Phosphorylation PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
K394 Methylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
T909 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus
C931 Methylation IEDB 31844290
S961 Phosphorylation PhosphoSitePlus
T972 Phosphorylation PhosphoSitePlus
T973 Phosphorylation PhosphoSitePlus
S974 Phosphorylation PhosphoSitePlus
S975 Phosphorylation PhosphoSitePlus
K979 Acetylation PhosphoSitePlus
S984 Phosphorylation PhosphoSitePlus
T985 Phosphorylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus   UniProt 23186163
S994 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1005 Phosphorylation PhosphoSitePlus
S1031 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1137 Phosphorylation PhosphoSitePlus
S1275 Phosphorylation PhosphoSitePlus
S1283 Phosphorylation PhosphoSitePlus
S1298 Phosphorylation PhosphoSitePlus
S1335 Phosphorylation PhosphoSitePlus   UniProt 24275569
T1425 Phosphorylation PhosphoSitePlus
T1433 Phosphorylation PhosphoSitePlus
S1437 O-Glycosylation GlyGen 32938750
S1440 O-Glycosylation GlyGen 29351928
S1464 Phosphorylation PhosphoSitePlus
R1538 Methylation PhosphoSitePlus
R1547 Methylation PhosphoSitePlus
T1558 Phosphorylation PhosphoSitePlus
S1563 Phosphorylation PhosphoSitePlus
T1564 Phosphorylation PhosphoSitePlus
Y1632 Phosphorylation PhosphoSitePlus
S1659 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1663 Phosphorylation PhosphoSitePlus
S1729 Phosphorylation PhosphoSitePlus
S1749 Phosphorylation PhosphoSitePlus
Y1763 Phosphorylation PhosphoSitePlus
S1766 Phosphorylation PhosphoSitePlus
S1767 Phosphorylation PhosphoSitePlus
K1833 Acetylation PhosphoSitePlus
Y1873 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 N61 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S61 G61 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S284 L284 Biomuta DOID:3571 / liver cancer [ cosmic ]
R292 C292 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1005 A1005 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1275 R1275 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1283 P1283 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1729 L1729 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1749 T1749 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1749 N1749 Biomuta DOID:3571 / liver cancer [ cosmic ]