iPTMnet Report for Q9UPR3 (SMG5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPR3 / SMG5_HUMAN
Protein Name Nonsense-mediated mRNA decay factor SMG5
Gene Name Name: SMG5
Synonyms:EST1B;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPR3
DAG View
PRO Name nonsense-mediated mRNA decay factor SMG5 (human)
Definition A nonsense-mediated mRNA decay factor SMG5 that is encoded in the genome of human.
Short Label hSMG5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPR3 (SMG5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
K49 Ubiquitination PhosphoSitePlus
K267 Acetylation PhosphoSitePlus
K273 Acetylation PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
S493 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
T538 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S838 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
S929 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K273 N273 Biomuta DOID:4159 / skin cancer [ cosmic ]
S480 L480 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S490 G490 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S495 N495 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S495 R495 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S497 F497 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S838 F838 Biomuta DOID:4159 / skin cancer [ cosmic ]
K928 R928 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]