iPTMnet Report for Q9UPQ0 (LIMCH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPQ0 / LIMC1_HUMAN
Protein Name LIM and calponin homology domains-containing protein 1
Gene Name Name: LIMCH1
Synonyms:KIAA1102;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPQ0
DAG View
PRO Name LIM and calponin homology domains-containing protein 1 (human)
Definition A LIM and calponin homology domains-containing protein 1 that is encoded in the genome of human.
Short Label hLIMCH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPQ0 (LIMCH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K95 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K162 Methylation PhosphoSitePlus
S169 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
K171 Methylation PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S204 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S207 Phosphorylation PhosphoSitePlus   UniProt 23186163
S210 Phosphorylation PhosphoSitePlus
S212 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T215 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
S217 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569, 20068231
S225 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S233 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S274 Phosphorylation phospho.ELM 17081983
T277 Phosphorylation phospho.ELM 17081983
Y279 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus   UniProt 23186163
S299 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus   UniProt 23186163
T317 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
C333 S-Nitrosylation dbSNO 26338901
S377 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
S379 Phosphorylation PhosphoSitePlus
T402 Phosphorylation UniProt 23186163
Y446 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T472 Phosphorylation PhosphoSitePlus
S493 O-Glycosylation GlyGen 28411811, 30379171, 28657654, ...35254053, 31492838, 29485866, 28510447, 31373491, 29237092
S493 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935, 16964243, 17081983
T500 O-Glycosylation GlyGen 28411811, 30379171, 28657654, ...35254053, 31492838, 29485866, 28510447, 31373491, 29237092
T502 O-Glycosylation GlyGen 28411811, 30379171, 28657654, ...35254053, 31492838, 29485866, 28510447, 31373491, 29237092
T505 O-Glycosylation GlyGen 31373491
T506 O-Glycosylation GlyGen 28411811, 30379171, 28657654, ...35254053, 31492838, 29485866, 28510447, 31373491, 29237092
T515 Phosphorylation PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus   UniProt 18669648, 20068231
S518 O-Glycosylation GlyGen 31373491
S518 Phosphorylation PhosphoSitePlus   UniProt 23186163
S521 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S525 Phosphorylation PhosphoSitePlus
T529 Phosphorylation PhosphoSitePlus   UniProt 18669648
T537 Phosphorylation PhosphoSitePlus   UniProt 20068231
S542 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
K588 Methylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S601 Phosphorylation PhosphoSitePlus   UniProt 20068231
S611 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S656 O-Glycosylation GlyGen 31373491
S657 O-Glycosylation GlyGen 31492838, 29237092
S670 Phosphorylation PhosphoSitePlus   UniProt 23186163
T672 Phosphorylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus   UniProt 23186163
S710 Phosphorylation PhosphoSitePlus
S718 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 20068231, 17081983
T724 Phosphorylation PhosphoSitePlus   UniProt 20068231
S746 Phosphorylation PhosphoSitePlus
S750 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S875 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K886 Ubiquitination PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
T932 Phosphorylation PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus   UniProt 23186163
S973 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S975 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T164 Phosphorylation HPRD 20068231
S169 Phosphorylation HPRD 19651622, 17081983, 20068231
S188 Phosphorylation HPRD 17081983
S190 Phosphorylation HPRD 16964243, 17081983
S192 Phosphorylation HPRD 18767875, 18669648, 15302935, ...16964243
S201 Phosphorylation HPRD 19651622, 17081983
S204 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18212344
S207 Phosphorylation HPRD 19651622, 15302935, 18452278
S210 Phosphorylation HPRD 19651622, 17081983, 20068231
S212 Phosphorylation HPRD 19651622, 17081983, 20068231
T215 Phosphorylation HPRD 19651622, 18669648, 18212344, ...19415658, 17081983
S217 Phosphorylation HPRD 18212344, 18767875, 15302935, ...19651622, 18669648, 19415658, 20068231
S225 Phosphorylation HPRD 18669648, 17081983, 20068231
S226 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S231 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S233 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S235 Phosphorylation HPRD 19651622, 17081983
S274 Phosphorylation HPRD 17081983
T277 Phosphorylation HPRD 17081983
S297 Phosphorylation HPRD 19651622, 20068231
T300 Phosphorylation HPRD 17081983
T302 Phosphorylation HPRD 17081983
S303 Phosphorylation HPRD 19651622, 17081983, 20068231
S377 Phosphorylation HPRD 18669648, 17081983, 20068231
S469 Phosphorylation HPRD 19651622, 18669648, 20068231
S471 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
T472 Phosphorylation HPRD 19651622, 18669648
S493 Phosphorylation HPRD 15302935, 18212344
T500 Phosphorylation HPRD 20068231
T505 Phosphorylation HPRD 20068231
T506 Phosphorylation HPRD 20068231
S511 Phosphorylation HPRD 20068231
T515 Phosphorylation HPRD 20068231
S516 Phosphorylation HPRD 18669648, 20068231
S518 Phosphorylation HPRD 18669648
S521 Phosphorylation HPRD 18669648, 17081983, 20068231
S523 Phosphorylation HPRD 18767875, 18452278, 19651622, ...18669648, 19415658, 20068231
S525 Phosphorylation HPRD 18767875, 18669648, 20068231
T527 Phosphorylation HPRD 18669648
T529 Phosphorylation HPRD 18669648
T537 Phosphorylation HPRD 20068231
Y541 Phosphorylation HPRD 20068231
S542 Phosphorylation HPRD 20068231
S601 Phosphorylation HPRD 19651622, 18669648, 18212344, ...20068231
S670 Phosphorylation HPRD 19651622, 15302935, 18212344, ...20068231, 19415658
T672 Phosphorylation HPRD 17081983
S680 Phosphorylation HPRD 20068231
S681 Phosphorylation HPRD 17081983, 20068231
S718 Phosphorylation HPRD 19413330, 18491316, 16964243, ...19664994, 15302935, 18452278, 19651622, 18669648, 20068231
T724 Phosphorylation HPRD 19651622, 18669648, 20068231
S750 Phosphorylation HPRD 20068231
S875 Phosphorylation HPRD 19651622, 18669648, 18212344, ...20068231, 18452278
S907 Phosphorylation HPRD 18452278
S973 Phosphorylation HPRD 17081983, 18767875, 18452278, ...19651622, 18669648, 19415658, 20068231, 18212344
S975 Phosphorylation HPRD 18767875, 17081983, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S750 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S965 Phosphorylation PhosphoSitePlus
S972 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
T56 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
Y698 Phosphorylation PhosphoSitePlus
T702 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
T787 Phosphorylation PhosphoSitePlus
S793 Phosphorylation PhosphoSitePlus
Y797 Phosphorylation PhosphoSitePlus
K804 Methylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
S854 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus
S863 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
T885 Phosphorylation PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
S903 Phosphorylation PhosphoSitePlus
S906 Phosphorylation PhosphoSitePlus
S908 Phosphorylation PhosphoSitePlus
S910 Phosphorylation PhosphoSitePlus
T912 Phosphorylation PhosphoSitePlus
T914 Phosphorylation PhosphoSitePlus
T922 Phosphorylation PhosphoSitePlus
S927 Phosphorylation PhosphoSitePlus
S932 Phosphorylation PhosphoSitePlus
T938 Phosphorylation PhosphoSitePlus
T951 Phosphorylation PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus
S974 Phosphorylation PhosphoSitePlus
S986 Phosphorylation PhosphoSitePlus
S1006 Phosphorylation PhosphoSitePlus
S1055 Phosphorylation PhosphoSitePlus
T1057 Phosphorylation PhosphoSitePlus
S1065 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
S1095 Phosphorylation PhosphoSitePlus
S1103 Phosphorylation PhosphoSitePlus
T1109 Phosphorylation PhosphoSitePlus
S1135 Phosphorylation PhosphoSitePlus
S1141 Phosphorylation PhosphoSitePlus
S1259 Phosphorylation PhosphoSitePlus
S1265 Phosphorylation PhosphoSitePlus
K1270 Ubiquitination PhosphoSitePlus
S1282 Phosphorylation PhosphoSitePlus
S1291 Phosphorylation PhosphoSitePlus
S1350 Phosphorylation PhosphoSitePlus
S1357 Phosphorylation PhosphoSitePlus
S1359 Phosphorylation PhosphoSitePlus
S1365 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S754 Phosphorylation PhosphoSitePlus
S769 Phosphorylation PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
S985 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S143 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K95 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K95 I95 Biomuta DOID:1324 / lung cancer [ cosmic ]
T164 A164 Biomuta DOID:263 / kidney cancer [ cosmic ]
S201 F201 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S207 F207 Biomuta DOID:4159 / skin cancer [ cosmic ]
S210 F210 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S217 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S231 C231 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
S233 C233 Biomuta DOID:1324 / lung cancer [ cosmic ]
S235 F235 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T277 S277 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T277 M277 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S320 C320 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S471 L471 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T505 A505 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S516 I516 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ]
S521 I521 Biomuta DOID:363 / uterine cancer [ icgc ]
S542 F542 Biomuta DOID:4159 / skin cancer [ icgc ]
S589 F589 Biomuta DOID:4159 / skin cancer [ cosmic ]
S596 Y596 Biomuta DOID:1324 / lung cancer [ cosmic ]
S601 F601 Biomuta DOID:4159 / skin cancer [ cosmic ]
S611 N611 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S621 C621 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S670 N670 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T672 I672 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S681 I681 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S750 Y750 Biomuta DOID:1324 / lung cancer [ cosmic ]
S754 F754 Biomuta DOID:363 / uterine cancer [ icgc ]
K886 N886 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S898 I898 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T932 R932 Biomuta DOID:2394 / ovarian cancer [ cosmic ]