iPTMnet Report for Q9UPN9 (TRIM33)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPN9 / TRI33_HUMAN
Protein Name E3 ubiquitin-protein ligase TRIM33
Gene Name Name: TRIM33
Synonyms:KIAA1113,RFG7,TIF1G;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPN9
DAG View
PRO Name E3 ubiquitin-protein ligase TRIM33 (human)
Definition An E3 ubiquitin-protein ligase TRIM33 that is encoded in the genome of human.
Short Label hTRIM33
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPN9 (TRIM33) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S169 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K334 Sumoylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
R433 Methylation PhosphoSitePlus
R440 Methylation PhosphoSitePlus
R458 Methylation PhosphoSitePlus
K481 Sumoylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
T505 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
R515 Methylation PhosphoSitePlus   UniProt 24129315
Y524 Phosphorylation PhosphoSitePlus
R535 Methylation PhosphoSitePlus   UniProt 24129315
R555 Methylation IEDB   PhosphoSitePlus 27503676
R577 Methylation PhosphoSitePlus   UniProt 24129315
C582 S-Nitrosylation dbSNO 22178444
R591 Methylation PhosphoSitePlus   UniProt 24129315
R598 Methylation PhosphoSitePlus   UniProt 24129315
R604 Methylation PhosphoSitePlus   UniProt 24129315
Y610 Phosphorylation PhosphoSitePlus
S622 Phosphorylation PhosphoSitePlus
S634 O-Glycosylation GlyGen 33214551, 32938750, 35138101, ...30379171, 32574038, 34725712, 34019948, 35254053, 35132862, 35083852, 32119511, 28510447, 29237092
T638 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 35254053, 35132862, 35083852, 32119511, 28510447, 29237092
T639 O-Glycosylation GlyGen 32574038
T643 O-Glycosylation GlyGen 33214551, 35138101, 30379171, ...32574038, 34725712, 34019948, 35254053, 35132862, 35083852, 32119511, 28510447, 29237092
T643 Phosphorylation PhosphoSitePlus
S644 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S715 Phosphorylation RLIMS-P 25639486
S727 Phosphorylation PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
K763 Acetylation PhosphoSitePlus   UniProt 19608861
K763 Sumoylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
K769 Acetylation PhosphoSitePlus   UniProt 19608861
K769 Sumoylation PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
K776 Acetylation PhosphoSitePlus
K776 Sumoylation PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
K793 Acetylation PhosphoSitePlus
K793 Sumoylation PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
S803 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
S813 Phosphorylation PhosphoSitePlus
T815 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
T820 Phosphorylation PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
K839 Sumoylation PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
S856 Phosphorylation PhosphoSitePlus
K861 Acetylation PhosphoSitePlus
K861 Sumoylation PhosphoSitePlus
S862 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
S949 Phosphorylation PhosphoSitePlus
K950 Acetylation PhosphoSitePlus
K951 Acetylation PhosphoSitePlus
K953 Acetylation PhosphoSitePlus   UniProt 19608861
K953 Sumoylation PhosphoSitePlus
K953 Ubiquitination PhosphoSitePlus
S959 Phosphorylation PhosphoSitePlus
K998 Ubiquitination PhosphoSitePlus
K999 Ubiquitination PhosphoSitePlus
K1007 Sumoylation PhosphoSitePlus
K1007 Ubiquitination PhosphoSitePlus
K1033 Ubiquitination PhosphoSitePlus
Y1048 Phosphorylation PhosphoSitePlus
T1051 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1057 Sumoylation PhosphoSitePlus
K1057 Ubiquitination PhosphoSitePlus
K1067 Ubiquitination PhosphoSitePlus
T1102 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
S1105 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
K1118 Sumoylation PhosphoSitePlus
S1119 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1127 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S622 Phosphorylation HPRD 20068231
T643 Phosphorylation HPRD 20068231
S862 Phosphorylation HPRD 17322306, 18767875, 18669648, ...20068231
T1102 Phosphorylation HPRD 18669648, 19415658, 20068231, ...18452278
S1105 Phosphorylation HPRD 18669648, 19415658, 20068231, ...18452278
S1119 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
S622 Phosphorylation HPRD 20068231
T643 Phosphorylation HPRD 20068231
S862 Phosphorylation HPRD 17322306, 18767875, 18669648, ...20068231
S1043 Phosphorylation PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
T1085 Phosphorylation HPRD 18669648, 19415658, 20068231, ...18452278
S1088 Phosphorylation HPRD 18669648, 19415658, 20068231, ...18452278
S1102 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35222 (CTNNB1) S715 Q9UPN9 (TRIM33) unknown eFIP 25639486


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S169 C169 Biomuta DOID:11934 / head and neck cancer [ icgc ]
S169 N169 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K334 N334 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
R440 C440 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
R440 H440 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R458 C458 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R515 Q515 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R555 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R591 I591 Biomuta DOID:1612 / breast cancer [ cosmic ]
R604 S604 Biomuta DOID:1324 / lung cancer [ cosmic ]
T643 M643 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S644 N644 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S727 F727 Biomuta DOID:1612 / breast cancer [ cosmic ]
S789 L789 Biomuta DOID:1319 / brain cancer [ cosmic ]
T820 N820 Biomuta DOID:3571 / liver cancer [ cosmic ]
S852 T852 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K950 R950 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1033 N1033 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1057 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
T1085 A1085 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1088 F1088 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1088 C1088 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T1102 A1102 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1105 C1105 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1105 F1105 Biomuta DOID:363 / uterine cancer [ icgc ]