Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPN6 / SCAF8_HUMAN
Protein Name SR-related and CTD-associated factor 8
Gene Name Name: SCAF8
Synonyms:CCAP7;
Organism Homo sapiens (Human)

PRO ID PR:Q9UPN6
DAG View
PRO Name SR-related and CTD-associated factor 8 (human)
Definition An SR-related and CTD-associated factor 8 that is encoded in the genome of human.
Short Label hSCAF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPN6 (SCAF8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus   UniProt 20388717
Y12 Phosphorylation PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
K18 Sumoylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S89 O-Glycosylation GlyGen 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
T95 O-Glycosylation GlyGen 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
K119 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus   UniProt 23186163
K281 Ubiquitination PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K461 Acetylation PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
K609 Acetylation PhosphoSitePlus
T611 O-Glycosylation GlyGen 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
T611 Phosphorylation PhosphoSitePlus
T614 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
T615 O-Glycosylation GlyGen   PhosphoSitePlus 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
T615 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
S617 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 15302935, ...21406692, 18669648
T619 Phosphorylation PhosphoSitePlus
S686 O-Glycosylation GlyGen 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
S779 Phosphorylation PhosphoSitePlus   UniProt 23186163
S780 Phosphorylation PhosphoSitePlus
S821 O-Glycosylation GlyGen 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
S822 O-Glycosylation GlyGen 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
S824 O-Glycosylation GlyGen 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
S861 O-Glycosylation GlyGen 23301498, 27114449, 30059200, ...29351928, 22661428, 28510447, 28657654, 20068230
R917 Methylation PhosphoSitePlus   UniProt 24129315
R927 Methylation PhosphoSitePlus   UniProt 24129315
R938 Methylation PhosphoSitePlus   UniProt 24129315
R967 Methylation PhosphoSitePlus
R981 Methylation PhosphoSitePlus
R988 Methylation PhosphoSitePlus
R1062 Methylation PhosphoSitePlus
R1073 Methylation PhosphoSitePlus
K1091 Ubiquitination PhosphoSitePlus
R1120 Methylation PhosphoSitePlus
R1122 Methylation PhosphoSitePlus
R1124 Methylation PhosphoSitePlus
R1129 Methylation PhosphoSitePlus
R1133 Methylation PhosphoSitePlus
R1139 Methylation PhosphoSitePlus
Y1198 Phosphorylation PhosphoSitePlus
Y1237 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S447 Phosphorylation HPRD 19651622
T614 Phosphorylation HPRD 19651622
T615 Phosphorylation HPRD 17525332, 18077418, 20068231
S617 Phosphorylation HPRD 19413330, 17322306, 18077418, ...19664994, 19664995, 18452278, 19651622, 18669648, 20068231
T619 Phosphorylation HPRD 19413330, 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S22 L22 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K81 R81 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K81 N81 Biomuta DOID:363 / uterine cancer [ tcga ]
K281 N281 Biomuta DOID:1115 / sarcoma [ tcga ]
S445 L445 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S447 L447 Biomuta DOID:1324 / lung cancer [ cosmic ]
K542 M542 Biomuta DOID:263 / kidney cancer [ tcga ]
K609 * Biomuta DOID:1324 / lung cancer [ tcga ]
T611 M611 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T614 R614 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S617 N617 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S822 I822 Biomuta DOID:363 / uterine cancer [ tcga ]
R927 C927 Biomuta DOID:1909 / melanoma [ cosmic ]
R938 K938 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
R967 G967 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R981 I981 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R1124 W1124 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:1612 / breast cancer [ tcga ] DOID:1909 / melanoma [ cosmic ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:169 / neuroendocrine tumor [ tcga ]
R1129 * Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1909 / melanoma [ tcga ] DOID:1324 / lung cancer [ cosmic ]
R1129 Q1129 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R1133 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R1139 Q1139 Biomuta DOID:10283 / prostate cancer [ cosmic ]