iPTMnet Report for Q9UPM8 (AP4E1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UPM8 / AP4E1_HUMAN
Protein Name AP-4 complex subunit epsilon-1
Gene Name Name: AP4E1
Organism Homo sapiens (Human)

PRO ID PR:Q9UPM8
DAG View
PRO Name AP-4 complex subunit epsilon-1 (human)
Definition An AP-4 complex subunit epsilon-1 that is encoded in the genome of human.
Short Label hAP4E1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UPM8 (AP4E1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
T8 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
Y229 Phosphorylation PhosphoSitePlus
T244 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
T393 Phosphorylation IEDB 31848261
S605 Phosphorylation PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
Y662 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
K696 Methylation PhosphoSitePlus
S700 Phosphorylation PhosphoSitePlus   UniProt 23186163
K708 Acetylation IEDB 34357683
T723 Phosphorylation PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
S751 Phosphorylation PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
Y830 Phosphorylation PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
K845 Ubiquitination PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S850 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S857 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S868 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
K955 Ubiquitination PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
S1137 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y398 Phosphorylation HPRD 20068231
T407 Phosphorylation HPRD 20068231
S850 Phosphorylation HPRD 18669648
S857 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S225 C225 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T244 A244 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S676 C676 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K708 T708 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K748 N748 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S797 L797 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S797 T797 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S832 L832 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S847 Y847 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S847 P847 Biomuta DOID:4159 / skin cancer [ cosmic ]