iPTMnet Report for Q9UP95 (SLC12A4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UP95 / S12A4_HUMAN
Protein Name Solute carrier family 12 member 4
Gene Name Name: SLC12A4
Synonyms:KCC1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UP95
DAG View
PRO Name solute carrier family 12 member 4 (human)
Definition A solute carrier family 12 member 4 that is encoded in the genome of human.
Short Label hSLC12A4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UP95 (SLC12A4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation Q9UEW8 (STK39) PhosphoSitePlus 24393035
Y17 Phosphorylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y28 Phosphorylation PhosphoSitePlus
S37 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S46 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S47 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S51 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S56 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y89 Phosphorylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
N312 N-Glycosylation UniProt 31649201
N361 N-Glycosylation UniProt 31649201
S407 Phosphorylation PhosphoSitePlus
Y411 Phosphorylation PhosphoSitePlus
T418 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus
K535 Acetylation PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
T725 Phosphorylation PhosphoSitePlus
S734 Phosphorylation UniProt 34031912
K757 Methylation PhosphoSitePlus
S836 Phosphorylation PhosphoSitePlus
T926 Phosphorylation PhosphoSitePlus
K943 Acetylation PhosphoSitePlus
K954 Ubiquitination PhosphoSitePlus
S964 Phosphorylation PhosphoSitePlus
S967 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...19690332, 20068231
T983 Phosphorylation Q9UEW8 (STK39) PhosphoSitePlus   UniProt 24393035, 23186163
K988 Ubiquitination PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
T1021 Phosphorylation PhosphoSitePlus
S1050 Phosphorylation UniProt 34031912
Y1056 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation HPRD 18669648, 20068231
S46 Phosphorylation HPRD 18669648, 20068231
S47 Phosphorylation HPRD 18578522, 18669648
S51 Phosphorylation HPRD 18669648, 20068231
S88 Phosphorylation HPRD 18578522
T926 Phosphorylation HPRD 20068231
S964 Phosphorylation HPRD 18578522
S967 Phosphorylation HPRD 18578522, 20058876, 19664994, ...18452278, 19651622, 18669648, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y61 C61 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
N312 S312 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K707 T707 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T725 I725 Biomuta [ cosmic ]
S734 N734 Biomuta DOID:1324 / lung cancer [ cosmic ]
K757 R757 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S836 N836 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K943 N943 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T983 M983 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]