iPTMnet Report for Q9UP52 (TFR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UP52 / TFR2_HUMAN
Protein Name Transferrin receptor protein 2
Gene Name Name: TFR2
Organism Homo sapiens (Human)

PRO ID PR:Q9UP52
DAG View
PRO Name transferrin receptor protein 2 (human)
Definition A transferrin receptor protein 2 that is encoded in the genome of human.
Short Label hTFR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UP52 (TFR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y23 Phosphorylation PhosphoSitePlus
R25 Methylation PhosphoSitePlus
R30 Methylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
N240 N-Glycosylation GlyGen 23556518
N339 N-Glycosylation GlyGen   UniProt 23556518, 19159218
N540 N-Glycosylation GlyGen 23556518
K609 Ubiquitination PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
N754 N-Glycosylation GlyGen   UniProt 23556518, 19159218
T765 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R25 S25 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R25 H25 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R30 Q30 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
N339 I339 Biomuta DOID:1785 / pituitary cancer [ cosmic ]