iPTMnet Report for Q9UNU6 (CYP8B1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UNU6 / CP8B1_HUMAN
Protein Name 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Gene Name Name: CYP8B1
Synonyms:CYP12;
Organism Homo sapiens (Human)

PRO ID PR:Q9UNU6
DAG View
PRO Name 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (human)
Definition A cytochrome P450 8B1 that is encoded in the genome of human.
Short Label hCYP8B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UNU6 (CYP8B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T62 Phosphorylation PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
T78 Phosphorylation PhosphoSitePlus
S127 Phosphorylation HPRD   PhosphoSitePlus 20166139
S269 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus   UniProt 24275569
T347 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T62 S62 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T62 A62 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y76 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T347 M347 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T347 K347 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S369 Y369 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S369 F369 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]