iPTMnet Report for Q9UNS2 (COPS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UNS2 / CSN3_HUMAN
Protein Name COP9 signalosome complex subunit 3
Gene Name Name: COPS3
Synonyms:CSN3;
Organism Homo sapiens (Human)

PRO ID PR:Q9UNS2
DAG View
PRO Name COP9 signalosome complex subunit 3 (human)
Definition A COP9 signalosome complex subunit 3 that is encoded in the genome of human.
Short Label hCOPS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UNS2 (COPS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...18850735
S3 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
Y367 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S410 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 18669648
S415 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S421 O-Glycosylation GlyGen 31373491
S421 Phosphorylation PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...18850735
Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD 18491316
Y244 Phosphorylation HPRD 20068231
T245 Phosphorylation HPRD 20068231
S410 Phosphorylation HPRD 19413330, 17525332, 18669648, ...20068231
S421 Phosphorylation HPRD 19413330, 19651622, 20068231
Y422 Phosphorylation HPRD 18669648
S423 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664995, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 T2 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K125 E125 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K156 E156 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y227 H227 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y227 F227 Biomuta DOID:1324 / lung cancer [ cosmic ]
K254 N254 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S273 L273 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K281 R281 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S350 G350 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K366 T366 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S415 L415 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S421 N421 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S421 I421 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]