iPTMnet Report for Q9UNS1 (TIMELESS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UNS1 / TIM_HUMAN
Protein Name Protein timeless homolog
Gene Name Name: TIMELESS
Synonyms:TIM;
Organism Homo sapiens (Human)

PRO ID PR:Q9UNS1
DAG View
PRO Name protein timeless homolog (human)
Definition A protein timeless that is encoded in the genome of human.
Short Label hTIMELESS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UNS1 (TIMELESS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y41 Phosphorylation PhosphoSitePlus
R246 Methylation PhosphoSitePlus
R267 Methylation PhosphoSitePlus
R271 Methylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y282 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K299 Acetylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
R305 Methylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
C493 Methylation IEDB 31844290
K687 Ubiquitination PhosphoSitePlus
T804 Phosphorylation PhosphoSitePlus
Y807 Phosphorylation PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
R813 Methylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
S816 Phosphorylation PhosphoSitePlus
T821 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
K838 Ubiquitination PhosphoSitePlus
K861 Ubiquitination PhosphoSitePlus
S962 Phosphorylation PhosphoSitePlus
S1074 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1078 Phosphorylation PhosphoSitePlus
K1085 Acetylation PhosphoSitePlus
K1085 Ubiquitination PhosphoSitePlus
S1087 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T1089 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1099 Phosphorylation PhosphoSitePlus
K1106 Ubiquitination PhosphoSitePlus
S1121 Phosphorylation PhosphoSitePlus
K1127 Ubiquitination PhosphoSitePlus
K1142 Acetylation PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 19690332, ...20068231
S1173 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 19690332, 20068231, 16964243
Y1200 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y282 Phosphorylation HPRD 18452278
S1087 Phosphorylation HPRD 18669648, 19691289, 20068231
T1089 Phosphorylation HPRD 18669648, 17924679
S1149 Phosphorylation HPRD 19413330, 19664994, 19691289, ...20068231
S1173 Phosphorylation HPRD 19413330, 18691976, 18767875, ...15302935, 19691289, 18452278, 19651622, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R267 Q267 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R305 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S309 L309 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y807 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
S809 P809 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T821 A821 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S962 Y962 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1085 R1085 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1121 C1121 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S1121 F1121 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1173 I1173 Biomuta DOID:9256 / colorectal cancer [ cosmic ]