iPTMnet Report for Q9UNF0 (PACSIN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UNF0 / PACN2_HUMAN
Protein Name Protein kinase C and casein kinase substrate in neurons protein 2
Gene Name Name: PACSIN2
Organism Homo sapiens (Human)

PRO ID PR:Q9UNF0
DAG View
PRO Name protein kinase C and casein kinase substrate in neurons protein 2 (human)
Definition A protein kinase C and casein kinase substrate in neurons protein 2 that is encoded in the genome of human.
Short Label hPACSIN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UNF0 (PACSIN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus
C44 Methylation IEDB 31844290
K53 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus   UniProt 23186163
R284 Methylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
T370 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S372 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T373 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
T380 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
Y388 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
T396 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S399 Phosphorylation PhosphoSitePlus
S403 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S425 Phosphorylation PhosphoSitePlus
S446 Phosphorylation PhosphoSitePlus   UniProt 23186163
K455 Ubiquitination PhosphoSitePlus
C465 S-Nitrosylation dbSNO 26338901
Site PTM Type PTM Enzyme Score Source PMID
S357 Phosphorylation HPRD 17081983
S359 Phosphorylation HPRD 17081983
S360 Phosphorylation HPRD 17081983
T370 Phosphorylation HPRD 18669648, 17081983
S372 Phosphorylation HPRD 18669648, 17081983
T373 Phosphorylation HPRD 17081983
S375 Phosphorylation HPRD 17081983
T396 Phosphorylation HPRD 18669648
S399 Phosphorylation HPRD 18452278
S403 Phosphorylation HPRD 18669648, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S336 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K188 N188 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S305 F305 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S372 N372 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S403 C403 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S425 L425 Biomuta DOID:5158 / pleural cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]