iPTMnet Report for Q9UNA4 (POLI)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UNA4 / POLI_HUMAN
Protein Name DNA polymerase iota
Gene Name Name: POLI
Synonyms:RAD30B;
Organism Homo sapiens (Human)

PRO ID PR:Q9UNA4
DAG View
PRO Name DNA polymerase iota (human)
Definition A DNA polymerase iota that is encoded in the genome of human.
Short Label hPOLI
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UNA4 (POLI) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K78 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
Y451 Phosphorylation PhosphoSitePlus
T459 Phosphorylation HPRD 17322306
S463 Phosphorylation PhosphoSitePlus
K465 Acetylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
K511 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
K551 Methylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K555 Methylation PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
K575 Acetylation PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
S658 Phosphorylation PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
Y714 Phosphorylation PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
K740 Acetylation PhosphoSitePlus
K740 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9NYV6 (RRN3) S172 Q9UNA4 (POLI) unknown eFIP 18559419
Phosphorylation Q9NYV6 (RRN3) T200 Q9UNA4 (POLI) inhibited_association eFIP 15805466
Phosphorylation Q9NYV6 (RRN3) S649 Q9UNA4 (POLI) unknown eFIP 15558034
Phosphorylation Q9NYV6 (RRN3) S172 Q9UNA4 (POLI) unknown eFIP 27257073


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K239 T239 Biomuta DOID:363 / uterine cancer [ icgc ]
K292 E292 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K296 E296 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y374 H374 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y380 N380 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y380 C380 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S463 P463 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S502 F502 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S565 T565 Biomuta DOID:263 / kidney cancer [ cosmic ]
K574 E574 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S658 L658 Biomuta [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
Y714 D714 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K729 N729 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]