Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9UNA0 / ATS5_HUMAN
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor
Gene Name Name: ADAMTS5
Organism Homo sapiens (Human)

DAG View
PRO Name a disintegrin and metalloproteinase with thrombospondin motifs 5 (human)
Definition An a disintegrin and metalloproteinase with thrombospondin motifs 5 that is encoded in the genome of human.
Short Label hADAMTS5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9UNA0 (ADAMTS5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T36 O-Glycosylation PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
S208 O-Glycosylation PhosphoSitePlus
S214 O-Glycosylation PhosphoSitePlus
T215 O-Glycosylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
N498 N-Glycosylation UniProt 18042673
W570 C-Glycosylation UniProt 19671700
W573 C-Glycosylation UniProt 19671700
S582 O-Glycosylation UniProt 19671700
K720 Ubiquitination PhosphoSitePlus
T746 Phosphorylation PhosphoSitePlus
K858 Acetylation PhosphoSitePlus
T899 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y92 C92 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y92 F92 Biomuta DOID:1612 / breast cancer [ tcga ]
K720 R720 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T746 I746 Biomuta DOID:1909 / melanoma [ cosmic ]
T899 M899 Biomuta DOID:5041 / esophageal cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]