iPTMnet Report Q9UNA0 ADAMTS5

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9UNA0 / ATS5_HUMAN
Protein Name	A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor
Gene Name	Name: ADAMTS5 Synonyms:ADAMTS11,ADMP2;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9UNA0 DAG View
PRO Name	a disintegrin and metalloproteinase with thrombospondin motifs 5 (human)
Definition	An a disintegrin and metalloproteinase with thrombospondin motifs 5 that is encoded in the genome of human.
Short Label	hADAMTS5
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9UNA0 (ADAMTS5) as Substrate

Q9UNA0

Expanded View

Search:

	Site Select all By amino acid All Serine All Threonine All Tyrosine By position T36 Y81 Y89 Y92 S208 S214 T215 S440 S441 T444 N498 W570 W573 S582 K720 T746 K858 T899	PTM Type Select all Acetylation C-Glycosylation N-Glycosylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3	Source Select all GlyGen PhosphoSitePlus UniProt	PMID
	T36	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 30459171, 30237853
	Y81	Phosphorylation		score1	PhosphoSitePlus
	Y89	Phosphorylation		score1	PhosphoSitePlus
	Y92	Phosphorylation		score1	PhosphoSitePlus
	S208	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533
	S214	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533
	T215	O-Glycosylation		score2	GlyGen PhosphoSitePlus	23584533, 30459171
	S440	Phosphorylation		score1	PhosphoSitePlus
	S441	Phosphorylation		score1	PhosphoSitePlus
	T444	Phosphorylation		score1	PhosphoSitePlus
	N498	N-Glycosylation		score3	GlyGen UniProt	18042673
	W570	C-Glycosylation		score3	GlyGen UniProt	19671700
	W573	C-Glycosylation		score3	GlyGen UniProt	19671700
	S582	O-Glycosylation		score3	GlyGen UniProt	19671700
	K720	Ubiquitination		score1	PhosphoSitePlus
	T746	Phosphorylation		score1	PhosphoSitePlus
	K858	Acetylation		score1	PhosphoSitePlus
	T899	Phosphorylation		score1	PhosphoSitePlus

PTM sites affected in variants

Search:

Site Select all By amino acid All Threonine All Tyrosine By position T36 Y92 W570 W573 K720 T746 T899	Variant Select all * C570 C92 F92 I746 M899 N36 R720	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T36	N36	Biomuta		DOID:2531 / hematologic cancer [ cosmic ]
Y92	C92	Biomuta		DOID:10534 / stomach cancer [ cosmic, icgc ]
Y92	F92	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]
W570	*	Biomuta		DOID:4159 / skin cancer [ cosmic ]
W570	C570	Biomuta		DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
W573	*	Biomuta		DOID:4606 / bile duct cancer [ cosmic ]
K720	R720	Biomuta		DOID:3571 / liver cancer [ cosmic ]
T746	I746	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]
T899	M899	Biomuta		DOID:1793 / pancreatic cancer [ cosmic ]