iPTMnet Report for Q9UNA0 (ADAMTS5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UNA0 / ATS5_HUMAN
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor
Gene Name Name: ADAMTS5
Synonyms:ADAMTS11,ADMP2;
Organism Homo sapiens (Human)

PRO ID PR:Q9UNA0
DAG View
PRO Name a disintegrin and metalloproteinase with thrombospondin motifs 5 (human)
Definition An a disintegrin and metalloproteinase with thrombospondin motifs 5 that is encoded in the genome of human.
Short Label hADAMTS5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UNA0 (ADAMTS5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T36 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 30237853
Y81 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
S208 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S214 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T215 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
S440 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
N498 N-Glycosylation GlyGen   UniProt 18042673
W570 C-Glycosylation GlyGen   UniProt 19671700
W573 C-Glycosylation GlyGen   UniProt 19671700
S582 O-Glycosylation GlyGen   UniProt 19671700
K720 Ubiquitination PhosphoSitePlus
T746 Phosphorylation PhosphoSitePlus
K858 Acetylation PhosphoSitePlus
T899 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T36 N36 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y92 C92 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y92 F92 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
W570 * Biomuta DOID:4159 / skin cancer [ cosmic ]
W570 C570 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
W573 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K720 R720 Biomuta DOID:3571 / liver cancer [ cosmic ]
T746 I746 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T899 M899 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]