Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UN86 / G3BP2_HUMAN
Protein Name Ras GTPase-activating protein-binding protein 2
Gene Name Name: G3BP2
Synonyms:KIAA0660;
Organism Homo sapiens (Human)

PRO ID PR:Q9UN86
DAG View
PRO Name Ras GTPase-activating protein-binding protein 2 (human)
Definition A Ras GTPase-activating protein-binding protein 2 that is encoded in the genome of human.
Short Label hG3BP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UN86 (G3BP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
R32 Methylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S141 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 17081983, ...18669648, 19690332
S149 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 17081983, ...18669648, 19690332
S163 Phosphorylation PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
T206 Phosphorylation PhosphoSitePlus
S225 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T226 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T227 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S235 O-Glycosylation GlyGen 22121020, 28657654
S235 Phosphorylation phospho.ELM 18669648
S245 O-Glycosylation GlyGen 22121020, 28657654
K281 Sumoylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
T364 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
R418 Methylation PhosphoSitePlus
R432 Methylation PhosphoSitePlus
R438 Methylation PhosphoSitePlus
R447 Methylation PhosphoSitePlus
R452 Methylation PhosphoSitePlus
R457 Methylation PhosphoSitePlus   UniProt 24129315
S466 Phosphorylation PhosphoSitePlus   UniProt 23186163
R468 Methylation PhosphoSitePlus   UniProt 24129315
R476 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T111 Phosphorylation HPRD 20068231
S141 Phosphorylation HPRD 18691976, 17081983, 19664995, ...18452278, 19651622, 18669648
S149 Phosphorylation HPRD 18691976, 17081983, 19664995, ...18452278, 19651622, 18669648
S173 Phosphorylation HPRD 17081983
Y175 Phosphorylation HPRD 17081983
S225 Phosphorylation HPRD 19413330, 19664995
T226 Phosphorylation HPRD 19413330, 19664995
T227 Phosphorylation HPRD 19413330, 17322306, 18491316, ...18767875, 19664995, 18452278, 19651622
Site PTM Type PTM Enzyme Score Source PMID
T111 Phosphorylation HPRD 20068231
S141 Phosphorylation HPRD   phospho.ELM 18691976, 17081983, 19664995, ...18452278, 19651622, 18669648
S149 Phosphorylation HPRD   phospho.ELM 18691976, 17081983, 19664995, ...18452278, 19651622, 18669648
S173 Phosphorylation HPRD 17081983
Y175 Phosphorylation HPRD 17081983
S225 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17081983, 19664995, ...18452278, 18669648, 20068231
T226 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18491316, 17081983, ...19664995, 18669648
T227 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18491316, 17287340, ...20230923, 18767875, 19664995, 18452278, 19651622, 17322306, 18669648, 20068231
S235 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17287340, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R32 M32 Biomuta DOID:363 / uterine cancer [ tcga ]
K123 T123 Biomuta DOID:363 / uterine cancer [ tcga ]
S225 C225 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T364 I364 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R418 T418 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R432 Q432 Biomuta DOID:0070003 / blastoma [ cosmic ]
R438 H438 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R438 C438 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R447 C447 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R452 T452 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]