iPTMnet Report for Q9UN36 (NDRG2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UN36 / NDRG2_HUMAN
Protein Name Protein NDRG2
Gene Name Name: NDRG2
Synonyms:KIAA1248,SYLD;
Organism Homo sapiens (Human)

PRO ID PR:Q9UN36
DAG View
PRO Name protein NDRG2 (human)
Definition A protein NDRG2 that is encoded in the genome of human.
Short Label hNDRG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UN36 (NDRG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
T20 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y47 Phosphorylation PhosphoSitePlus
T57 Phosphorylation PhosphoSitePlus
R247 Methylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus   UniProt 24275569
S328 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569
T330 Phosphorylation O00141 (SGK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 26500492, 15461589, ...18669648, 24275569
S332 Phosphorylation P23443 (RPS6KB1) , O00141 (SGK1) , P31749 (AKT1) , Q15418 (RPS6KA1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23558861, 26500492, 15461589, ...18669648, 24275569, 23186163, 19690332
T334 Phosphorylation PhosphoSitePlus   UniProt 24275569
S335 Phosphorylation PhosphoSitePlus
S338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...24275569
S344 Phosphorylation PhosphoSitePlus   UniProt 24275569
S346 Phosphorylation O00141 (SGK1) phospho.ELM   PhosphoSitePlus 15461589
T348 Phosphorylation P31749 (AKT1) , O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23558861, 26500492, 15461589, ...18669648, 19690332
S350 Phosphorylation Q15418 (RPS6KA1) , P23443 (RPS6KB1) phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 15461589, 28141794
S352 Phosphorylation PhosphoSitePlus
S353 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S355 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S326 Phosphorylation HPRD 20166139
S328 Phosphorylation HPRD 20166139, 18669648
T330 Phosphorylation HPRD 19413330, 19562805, 19664994, ...19651622, 18669648, 20166139
S332 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994, 20166139
T334 Phosphorylation HPRD 20166139
S335 Phosphorylation HPRD 20166139
S338 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994, 20166139
S346 Phosphorylation HPRD 20166139, 18077418
T348 Phosphorylation HPRD 19413330, 20166139, 18077418, ...18669648
S350 Phosphorylation HPRD 19413330, 20166139, 18077418, ...18669648
S352 Phosphorylation HPRD 19413330, 20166139
S353 Phosphorylation HPRD 19413330, 20166139, 18669648
S355 Phosphorylation HPRD 20166139, 18077418
Site PTM Type PTM Enzyme Score Source PMID
S312 Phosphorylation HPRD 20166139
S314 Phosphorylation HPRD 20166139, 18669648
T316 Phosphorylation HPRD 19413330, 19562805, 19664994, ...19651622, 18669648, 20166139
S318 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994, 20166139
T320 Phosphorylation HPRD 20166139
S321 Phosphorylation HPRD 20166139
S324 Phosphorylation HPRD 19413330, 19651622, 18669648, ...19664994, 20166139
S332 Phosphorylation HPRD 20166139, 18077418
T334 Phosphorylation HPRD 19413330, 20166139, 18077418, ...18669648
S336 Phosphorylation HPRD 19413330, 20166139, 18077418, ...18669648
S338 Phosphorylation HPRD 19413330, 20166139
S339 Phosphorylation HPRD 19413330, 20166139, 18669648
S341 Phosphorylation HPRD 20166139, 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S318 F318 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S332 F332 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S339 G339 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S353 G353 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S359 Y359 Biomuta DOID:363 / uterine cancer [ icgc ]
S360 L360 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S370 F370 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]