iPTMnet Report for Q9UN19 (DAPP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UN19 / DAPP1_HUMAN
Protein Name Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
Gene Name Name: DAPP1
Synonyms:BAM32;ORFNames:HSPC066;
Organism Homo sapiens (Human)

PRO ID PR:Q9UN19
DAG View
PRO Name dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (human)
Definition A dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide that is encoded in the genome of human.
Short Label hDAPP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UN19 (DAPP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K132 Ubiquitination PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18083107, 10880360, 15247305
Y139 Phosphorylation P06239 (LCK) phospho.ELM   PhosphoSitePlus 10880360
Y139 Phosphorylation P07948 (LYN) PhosphoSitePlus 10880360
Y139 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 10880360
S141 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K182 Acetylation PhosphoSitePlus
C213 Methylation IEDB 31844290
K263 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y139 Phosphorylation HPRD 19901323, 10880360, 17389395
Y139 Phosphorylation P06239 (LCK) HPRD 19901323, 10880360, 17389395
Y139 Phosphorylation P07948 (LYN) HPRD 19901323, 10880360, 17389395
Y139 Phosphorylation P12931 (SRC) HPRD 19901323, 10880360, 17389395
Y139 Phosphorylation Q06187 (BTK) HPRD 19901323, 10880360, 17389395


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S137 F137 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S141 Y141 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S141 F141 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]