iPTMnet Report for Q9UMN6 (KMT2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UMN6 / KMT2B_HUMAN
Protein Name Histone-lysine N-methyltransferase 2B
Gene Name Name: KMT2B
Synonyms:HRX2,KIAA0304,MLL2,MLL4,TRX2,WBP7;
Organism Homo sapiens (Human)

PRO ID PR:Q9UMN6
DAG View
PRO Name histone-lysine N-methyltransferase 2B (human)
Definition A histone-lysine N-methyltransferase 2B that is encoded in the genome of human.
Short Label hKMT2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UMN6 (KMT2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
R17 Methylation PhosphoSitePlus
R33 Methylation PhosphoSitePlus
R36 Methylation PhosphoSitePlus
R49 Methylation PhosphoSitePlus
T158 Phosphorylation HPRD 20068231
T159 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
T172 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T176 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
K180 Methylation PhosphoSitePlus
R181 Methylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
R217 Methylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
R222 Methylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
R280 Methylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S351 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19664995
T475 Phosphorylation PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
S500 Phosphorylation PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
K541 Methylation PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
T588 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
S632 Phosphorylation IEDB   PhosphoSitePlus 32387766
T653 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
T713 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus
K797 Methylation PhosphoSitePlus
K797 Ubiquitination PhosphoSitePlus
S821 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...18669648, 20068231
S844 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 23186163
S848 Phosphorylation HPRD 17081983
S857 Phosphorylation HPRD   PhosphoSitePlus 20068231
S861 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19664995, 18452278, 24275569, 20068231
T906 Phosphorylation PhosphoSitePlus
S910 Phosphorylation PhosphoSitePlus
S913 Phosphorylation PhosphoSitePlus
K926 Acetylation PhosphoSitePlus
S936 Phosphorylation PhosphoSitePlus   UniProt 23186163
S941 Phosphorylation PhosphoSitePlus
T948 Phosphorylation PhosphoSitePlus
S1032 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18452278
S1035 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18452278
S1039 Phosphorylation HPRD   PhosphoSitePlus 18452278
S1069 Phosphorylation PhosphoSitePlus
S1085 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S1095 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S1122 Phosphorylation PhosphoSitePlus
T1128 Phosphorylation PhosphoSitePlus
K1161 Methylation PhosphoSitePlus
S1164 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
Y1275 Phosphorylation PhosphoSitePlus
Y1284 Phosphorylation PhosphoSitePlus
S1519 Phosphorylation PhosphoSitePlus
T1550 Phosphorylation PhosphoSitePlus
K1567 Acetylation PhosphoSitePlus
K1692 Ubiquitination PhosphoSitePlus
Y1707 Phosphorylation PhosphoSitePlus
Y1783 Phosphorylation IEDB 35494241
T1803 Phosphorylation PhosphoSitePlus
S1807 Phosphorylation PhosphoSitePlus
S1836 Phosphorylation PhosphoSitePlus
K1866 Methylation PhosphoSitePlus
S1917 Phosphorylation PhosphoSitePlus
S1930 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K1934 Methylation PhosphoSitePlus
T1935 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1936 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2050 O-Glycosylation GlyGen 30379171, 35289036
T2068 Phosphorylation PhosphoSitePlus   UniProt 19690332
S2070 Phosphorylation HPRD   PhosphoSitePlus 18452278
T2083 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...19691289, 24275569, 19690332
S2086 Phosphorylation PhosphoSitePlus
K2185 Ubiquitination PhosphoSitePlus
K2196 Ubiquitination PhosphoSitePlus
K2203 Methylation PhosphoSitePlus
S2270 Phosphorylation HPRD   PhosphoSitePlus 20068231
T2283 Phosphorylation PhosphoSitePlus
S2288 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y2295 Phosphorylation PhosphoSitePlus
K2296 Acetylation PhosphoSitePlus
S2318 Phosphorylation PhosphoSitePlus
S2348 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2455 Phosphorylation PhosphoSitePlus
S2573 Phosphorylation PhosphoSitePlus
Y2604 Phosphorylation PhosphoSitePlus
S2605 Phosphorylation PhosphoSitePlus
S2611 O-Glycosylation GlyGen 30379171, 35289036
K2691 Ubiquitination PhosphoSitePlus
K2700 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T158 M158 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
T172 N172 Biomuta DOID:263 / kidney cancer [ icgc ]
T172 I172 Biomuta DOID:4159 / skin cancer [ icgc ]
T176 I176 Biomuta DOID:3571 / liver cancer [ cosmic ]
R181 W181 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R181 Q181 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S214 F214 Biomuta DOID:4159 / skin cancer [ cosmic ]
R217 W217 Biomuta DOID:263 / kidney cancer [ icgc ]
T475 I475 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
S582 F582 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S582 A582 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S602 P602 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S632 P632 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S703 N703 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S848 L848 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S857 L857 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S861 F861 Biomuta DOID:4159 / skin cancer [ cosmic ]
S936 P936 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1069 C1069 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1069 F1069 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S1095 L1095 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1783 * Biomuta DOID:3571 / liver cancer [ cosmic ]
T1803 I1803 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1836 L1836 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1917 I1917 Biomuta DOID:363 / uterine cancer [ icgc ]
S1936 F1936 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2083 M2083 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S2086 L2086 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ]
K2185 N2185 Biomuta [ cosmic ] DOID:1319 / brain cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K2196 N2196 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S2270 I2270 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S2288 F2288 Biomuta DOID:4159 / skin cancer [ cosmic ]
S2573 Y2573 Biomuta DOID:363 / uterine cancer [ icgc ]
K2700 N2700 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]