iPTMnet Report for Q9UM73 (ALK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UM73 / ALK_HUMAN
Protein Name ALK tyrosine kinase receptor precursor
Gene Name Name: ALK
Organism Homo sapiens (Human)

PRO ID PR:Q9UM73
DAG View
PRO Name ALK tyrosine kinase receptor (human)
Definition An ALK tyrosine kinase receptor that is encoded in the genome of human.
Short Label hALK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UM73 (ALK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y46 Phosphorylation PhosphoSitePlus
S47 Phosphorylation HPRD   PhosphoSitePlus 19664994
S62 Phosphorylation PhosphoSitePlus
S211 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16565220
S312 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
Y705 Phosphorylation RLIMS-P 27009859, 14506160
Y849 Phosphorylation PhosphoSitePlus
S1075 Phosphorylation PhosphoSitePlus
Y1078 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107
T1090 Phosphorylation PhosphoSitePlus
Y1092 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
Y1096 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107, 16878150
Y1131 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
Y1278 Phosphorylation Q9UM73 (ALK) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22992069, 18083107, 28245558, ...15592455, 30004444, 15938644
S1281 Phosphorylation PhosphoSitePlus
Y1282 Phosphorylation Q9UM73 (ALK) HPRD   phospho.ELM   PhosphoSitePlus 15592455, 9174053, 15938644, ...18083107
Y1283 Phosphorylation Q9UM73 (ALK) HPRD   IntAct   phospho.ELM   PhosphoSitePlus 17998938, 11110708, 9819383, ...9174053, 18083107
Y1359 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
Y1401 Phosphorylation PhosphoSitePlus
K1451 Methylation PhosphoSitePlus
K1455 Methylation PhosphoSitePlus
S1481 Phosphorylation PhosphoSitePlus
S1495 Phosphorylation PhosphoSitePlus
T1506 Phosphorylation PhosphoSitePlus
Y1507 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11110708, 9819383, 18083107, ...17274988, 15592455, 32344689
S1509 Phosphorylation PhosphoSitePlus
K1517 Ubiquitination PhosphoSitePlus
K1518 Ubiquitination PhosphoSitePlus
Y1584 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455
Y1586 Phosphorylation PhosphoSitePlus
T1597 Phosphorylation PhosphoSitePlus
Y1604 Phosphorylation Q9UM73 (ALK) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26418745, 21297104, 28030793, ...29907598, 25727400, 31334113, 9819383, 29755689, 27888620, 15592455, 31852910, 29515255
K1610 Methylation PhosphoSitePlus


Q9UM73 (ALK) as PTM Enzyme



Substrate Site Score Source PMID
P14618 (PKM) Y105 RLIMS-P+ 23814019
P23246 (SFPQ) Y293 PhosphoSitePlus   Signor 17537995
P31939 (ATIC) Y104 PhosphoSitePlus 18845790
P40763 (STAT3) Y705 phospho.ELM   PhosphoSitePlus 11850821
P42768 (WAS) Y102 RLIMS-P+ 27694894
P49841 (GSK3B) S9 RLIMS-P+ 22179823
P50552 (VASP) Y39 PhosphoSitePlus 18845790
P62993 (GRB2) Y160 PhosphoSitePlus   Signor 20554525
Q86WB0 (ZC3HC1) Y105 phospho.ELM 12748172
Q86WB0 (ZC3HC1) Y137 phospho.ELM 12748172
Q9C0H9-5 (SRCIN1) Y396 PhosphoSitePlus 23383002
Q9UM73 (ALK) Y1278 neXtProt   PhosphoSitePlus 15938644
Q9UM73 (ALK) Y1282 HPRD   phospho.ELM 9174053
Q9UM73 (ALK) Y1283 HPRD   phospho.ELM 9174053, 11110708, 9819383
Q9UM73 (ALK) Y1604 HPRD 9819383


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S62 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S62 L62 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S319 F319 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S329 F329 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1090 A1090 Biomuta DOID:363 / uterine cancer [ icgc ]
Y1278 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1278 S1278 Biomuta [ cosmic ]
Y1359 C1359 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1495 F1495 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1506 M1506 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S1509 F1509 Biomuta [ cosmic ]
K1518 N1518 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
Y1604 H1604 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1610 R1610 Biomuta DOID:1319 / brain cancer [ cosmic ]