iPTMnet Report for Q9UM54 (MYO6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UM54 / MYO6_HUMAN
Protein Name Unconventional myosin-VI
Gene Name Name: MYO6
Synonyms:KIAA0389;
Organism Homo sapiens (Human)

PRO ID PR:Q9UM54
DAG View
PRO Name unconventional myosin-VI (human)
Definition A myosin-VI that is encoded in the genome of human.
Short Label hMYO6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UM54 (MYO6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K56 Acetylation PhosphoSitePlus
K57 Acetylation PhosphoSitePlus
T72 Phosphorylation IEDB 33936100
K78 Ubiquitination PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus   UniProt 23186163
K285 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
K326 Acetylation PhosphoSitePlus
K334 Acetylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K408 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
C442 Methylation IEDB 31844290
K490 Ubiquitination PhosphoSitePlus
T558 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
S639 Phosphorylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K648 Ubiquitination PhosphoSitePlus
T649 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
T661 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
Y749 Phosphorylation PhosphoSitePlus
K750 Acetylation PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
K755 Ubiquitination PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
T845 Phosphorylation PhosphoSitePlus
S877 Phosphorylation PhosphoSitePlus
K886 Ubiquitination PhosphoSitePlus
T888 Phosphorylation PhosphoSitePlus
T891 Phosphorylation PhosphoSitePlus
K897 Ubiquitination PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
S1019 Phosphorylation PhosphoSitePlus
S1025 Phosphorylation IEDB   PhosphoSitePlus 35494241
K1052 Ubiquitination PhosphoSitePlus
T1054 Phosphorylation PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
K1076 Ubiquitination PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
K1090 Ubiquitination PhosphoSitePlus
K1119 Ubiquitination PhosphoSitePlus
Y1121 Phosphorylation PhosphoSitePlus
K1125 Ubiquitination PhosphoSitePlus
S1126 Phosphorylation PhosphoSitePlus
K1130 Ubiquitination PhosphoSitePlus
T1133 O-Glycosylation GlyGen 30379171, 34725712, 35138101, ...34229054, 30620550
T1135 O-Glycosylation GlyGen 30379171, 34725712, 35138101, ...34229054, 30620550
K1141 Ubiquitination PhosphoSitePlus
T1144 Phosphorylation PhosphoSitePlus
Y1146 Phosphorylation PhosphoSitePlus
S1155 Phosphorylation PhosphoSitePlus
Y1191 Phosphorylation PhosphoSitePlus
K1192 Ubiquitination PhosphoSitePlus
S1196 Phosphorylation PhosphoSitePlus
K1197 Ubiquitination PhosphoSitePlus
T1283 Phosphorylation PhosphoSitePlus
Y1284 Phosphorylation PhosphoSitePlus
K1294 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation HPRD 18452278
Y107 Phosphorylation HPRD 20068231
S108 Phosphorylation HPRD 20068231
S109 Phosphorylation HPRD 20068231
S114 Phosphorylation HPRD 20068231
Y115 Phosphorylation HPRD 20068231
T122 Phosphorylation HPRD 20068231
Y228 Phosphorylation HPRD 20068231
S266 Phosphorylation HPRD 20068231
T402 Phosphorylation HPRD 20068231
T405 Phosphorylation HPRD 20068231, 11517222
T405 Phosphorylation O75914 (PAK3) HPRD 20068231, 11517222
T888 Phosphorylation HPRD 18452278
T891 Phosphorylation HPRD 18452278
Y1137 Phosphorylation HPRD 17389395
Site PTM Type PTM Enzyme Score Source PMID
K1141 Ubiquitination PhosphoSitePlus
Y1146 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y1089 Phosphorylation PhosphoSitePlus
K1109 Ubiquitination PhosphoSitePlus
Y1114 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K1141 Ubiquitination PhosphoSitePlus
Y1146 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S108 F108 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y115 H115 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]