iPTMnet Report for Q9UM47 (NOTCH3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UM47 / NOTC3_HUMAN
Protein Name Neurogenic locus notch homolog protein 3 precursor
Gene Name Name: NOTCH3
Organism Homo sapiens (Human)

PRO ID PR:Q9UM47
DAG View
PRO Name neurogenic locus notch homolog protein 3 (human)
Definition A neurogenic locus notch homolog protein 3 that is encoded in the genome of human.
Short Label hNOTCH3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UM47 (NOTCH3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S84 Phosphorylation PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus
S725 O-Glycosylation GlyGen 28657654, 29351928
N851 N-Glycosylation GlyGen 23090970
N1179 N-Glycosylation GlyGen 23090970, 24190977
Y1197 Phosphorylation PhosphoSitePlus
T1198 O-Glycosylation GlyGen 28657654, 29351928
T1272 O-Glycosylation GlyGen 28657654, 29351928
T1274 O-Glycosylation GlyGen 28657654, 29351928
S1672 Phosphorylation PhosphoSitePlus
T1673 Phosphorylation PhosphoSitePlus
S1681 Phosphorylation PhosphoSitePlus
K1684 Ubiquitination PhosphoSitePlus
S1712 Phosphorylation PhosphoSitePlus
Y1849 Phosphorylation PhosphoSitePlus
T1908 Phosphorylation PhosphoSitePlus
K1971 Ubiquitination PhosphoSitePlus
K1989 Ubiquitination PhosphoSitePlus
S2032 Phosphorylation PhosphoSitePlus
K2069 Ubiquitination PhosphoSitePlus
R2174 Methylation PhosphoSitePlus   UniProt 24129315


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T211 I211 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y529 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y1197 * Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T1274 I1274 Biomuta DOID:1115 / sarcoma [ tcga ]
T1908 M1908 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]