iPTMnet Report for Q9UM11 (FZR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UM11 / FZR1_HUMAN
Protein Name Fizzy-related protein homolog
Gene Name Name: FZR1
Synonyms:CDH1;
Organism Homo sapiens (Human)

PRO ID PR:Q9UM11
DAG View
PRO Name fizzy-related protein homolog (human)
Definition A fizzy-related protein that is encoded in the genome of human.
Short Label hFZR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UM11 (FZR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
Y5 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
T32 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S35 Phosphorylation PhosphoSitePlus
S36 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S39 O-Glycosylation GlyGen   PhosphoSitePlus 27080259
S39 Phosphorylation PhosphoSitePlus
S40 O-Glycosylation GlyGen   PhosphoSitePlus 27080259
S40 Phosphorylation P24941 (CDK2) , Q00535 (CDK5) neXtProt   phospho.ELM   PhosphoSitePlus 18669648, 18818692, 26083744
S42 O-Glycosylation GlyGen   PhosphoSitePlus 27080259
S42 Phosphorylation PhosphoSitePlus
K69 Acetylation UniProt 22014574
S70 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S72 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K86 Ubiquitination PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
T121 Phosphorylation P24941 (CDK2) , Q00535 (CDK5) neXtProt   PhosphoSitePlus 18818692, 26083744
K125 Sumoylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus   UniProt 23186163
K135 Acetylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S137 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S138 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S146 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S151 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 12560341, 18669648, ...19690332, 26083744
S154 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K156 Ubiquitination PhosphoSitePlus
K159 Acetylation UniProt 22014574
S163 Phosphorylation Q00535 (CDK5) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus 12560341, 18818692, 26083744
K173 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T30 Phosphorylation HPRD 20068231
T32 Phosphorylation HPRD 18669648
S36 Phosphorylation HPRD 19413330, 18669648
S39 Phosphorylation HPRD 19413330
S40 Phosphorylation HPRD 18669648
S42 Phosphorylation HPRD 20068231
S137 Phosphorylation HPRD 18669648, 20068231
S138 Phosphorylation HPRD 18669648, 20068231
S146 Phosphorylation HPRD 18669648, 20068231
S149 Phosphorylation HPRD 20068231
S151 Phosphorylation P24941 (CDK2) HPRD 12560341, 18669648, 20068231
S154 Phosphorylation HPRD 18669648, 20068231
S163 Phosphorylation P24941 (CDK2) HPRD 12560341
K480 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047482 (hFZR1/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T32 K32 Biomuta DOID:4159 / skin cancer [ cosmic ]
T32 M32 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S70 F70 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K96 N96 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K125 E125 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S131 F131 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K135 T135 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S137 C137 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S149 F149 Biomuta DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
T300 P300 Biomuta DOID:1319 / brain cancer [ cosmic ]
S343 L343 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]