iPTMnet Report for Q9ULZ3 (PYCARD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9ULZ3 / ASC_HUMAN
Protein Name Apoptosis-associated speck-like protein containing a CARD
Gene Name Name: PYCARD
Synonyms:ASC;
Organism Homo sapiens (Human)

PRO ID PR:Q9ULZ3
DAG View
PRO Name apoptosis-associated speck-like protein containing a CARD (human)
Definition An apoptosis-associated speck-like protein containing a CARD that is encoded in the genome of human.
Short Label hPYCARD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9ULZ3 (PYCARD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K21 Acetylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S58 Phosphorylation RLIMS-P 25266676
Y60 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
Y146 Phosphorylation P43405 (SYK) , Q14289 (PTK2B) PhosphoSitePlus   RLIMS-P+   RLIMS-P 27796369, 25605870
S164 Phosphorylation PhosphoSitePlus
K174 Ubiquitination UniProt 25847972
Y187 Phosphorylation P43405 (SYK) RLIMS-P+ 25605870
S195 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96P20 (NLRP3) S295 Q9ULZ3 (PYCARD) inhibited_association eFIP 33627128


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K21 N21 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y137 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y146 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S195 R195 Biomuta DOID:1324 / lung cancer [ cosmic ]