iPTMnet Report for Q9ULX6 (AKAP8L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9ULX6 / AKP8L_HUMAN
Protein Name A-kinase anchor protein 8-like
Gene Name Name: AKAP8L
Synonyms:NAKAP,NAKAP95;ORFNames:HRIHFB2018;
Organism Homo sapiens (Human)

PRO ID PR:Q9ULX6
DAG View
PRO Name A-kinase anchor protein 8-like (human)
Definition An A-kinase anchor protein 8-like that is encoded in the genome of human.
Short Label hAKAP8L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9ULX6 (AKAP8L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y29 Phosphorylation PhosphoSitePlus
Y31 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
C128 S-Nitrosylation dbSNO 26338901
R131 Methylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
R171 Methylation PhosphoSitePlus
R179 Methylation PhosphoSitePlus
R185 Methylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
R191 Methylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus
R199 Methylation PhosphoSitePlus
R208 Methylation PhosphoSitePlus   UniProt 24129315
R217 Methylation PhosphoSitePlus   UniProt 24129315
R237 Methylation PhosphoSitePlus   UniProt 24129315
R247 Methylation PhosphoSitePlus   UniProt 24129315
K257 Acetylation PhosphoSitePlus   UniProt 19608861
K257 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus   UniProt 23186163
T268 Phosphorylation PhosphoSitePlus
R272 Methylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 15302935, 20068231
S289 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
T292 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T294 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S297 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S300 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S302 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T308 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T313 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
R397 Methylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K500 Acetylation PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
K520 Acetylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
K544 Sumoylation PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
T550 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus   UniProt 23186163
S601 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y31 C31 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R171 C171 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R185 G185 Biomuta DOID:4159 / skin cancer [ cosmic ]
R188 W188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R191 P191 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R199 H199 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R217 Q217 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R217 W217 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R272 L272 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S283 R283 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S289 N289 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K290 E290 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R397 W397 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T504 I504 Biomuta DOID:4159 / skin cancer [ cosmic ]