Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9ULW0 / TPX2_HUMAN
Protein Name Targeting protein for Xklp2
Gene Name Name: TPX2
Synonyms:C20orf1,C20orf2,DIL2,HCA519;
Organism Homo sapiens (Human)

PRO ID PR:Q9ULW0
DAG View
PRO Name targeting protein for Xklp2 (human)
Definition A targeting protein for Xklp2 that is encoded in the genome of human.
Short Label hTPX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9ULW0 (TPX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K44 Ubiquitination PhosphoSitePlus
K48 Sumoylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
T51 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K58 Acetylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
T59 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K63 Sumoylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
T72 Phosphorylation P06493 (CDK1) , P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 25688093, 18847512, ...16565220, 18669648, 20068231
K75 Acetylation PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
S110 Phosphorylation PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
S121 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 16565220, 18669648, ...17287340, 26240182
S125 Phosphorylation O14965 (AURKA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 16565220, 18669648, ...26240182, 17287340
K128 Acetylation PhosphoSitePlus
T147 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16565220
S157 Phosphorylation PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
T179 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
S186 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
T195 Phosphorylation PhosphoSitePlus
C198 S-Nitrosylation dbSNO 26338901
K203 Ubiquitination PhosphoSitePlus
K208 Sumoylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
K220 Sumoylation PhosphoSitePlus
K237 Sumoylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K256 Sumoylation PhosphoSitePlus
S257 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
T264 Phosphorylation PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
K279 Sumoylation PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
R288 Methylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus   UniProt 20068231
S293 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 20068231, 16565220
K305 Acetylation PhosphoSitePlus   UniProt 19608861
K305 Sumoylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
S310 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K313 Acetylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K314 Acetylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
T338 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16565220
S346 Phosphorylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
S358 Phosphorylation phospho.ELM 18669648
S359 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16565220
T361 Phosphorylation phospho.ELM 18669648
T369 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 22028470, 23186163, 16964243, ...16565220
T374 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K375 Acetylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
T382 Phosphorylation PhosphoSitePlus
K384 Sumoylation PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K401 Sumoylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
K476 Acetylation PhosphoSitePlus
K476 Sumoylation PhosphoSitePlus
K477 Sumoylation PhosphoSitePlus
T482 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
S486 Phosphorylation Q00535 (CDK5) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 23186163, 16964243, ...31272499, 16565220, 18669648, 20068231, 17924679
K492 Sumoylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
T499 Phosphorylation PhosphoSitePlus   UniProt 23186163
K500 Acetylation PhosphoSitePlus
K500 Sumoylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
Y519 Phosphorylation PhosphoSitePlus
K524 Acetylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S542 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K560 Sumoylation PhosphoSitePlus
K565 Sumoylation PhosphoSitePlus
K567 Sumoylation PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
K582 Acetylation PhosphoSitePlus
K585 Sumoylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
K604 Methylation PhosphoSitePlus
K604 Sumoylation PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
R617 Methylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
S634 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K641 Sumoylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
K645 Sumoylation PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
S652 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
S654 Phosphorylation phospho.ELM   PhosphoSitePlus 16565220
K666 Sumoylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
K720 Sumoylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
Y721 Phosphorylation PhosphoSitePlus
K727 Sumoylation PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
T734 Phosphorylation PhosphoSitePlus
S738 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...16964243, 19369195, 18234856, 15302935, 18669648, 29052541, 20068231
K740 Sumoylation PhosphoSitePlus
K740 Ubiquitination PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation HPRD 19007248
S21 Phosphorylation HPRD 19007248
T28 Phosphorylation HPRD 19007248
S33 Phosphorylation HPRD 19007248
T51 Phosphorylation HPRD 19007248, 16565220
T59 Phosphorylation HPRD 18669648
T72 Phosphorylation HPRD 18669648, 16565220, 19691289, ...20068231, 19007248
S94 Phosphorylation HPRD 19007248
T113 Phosphorylation HPRD 19007248
S121 Phosphorylation HPRD 18691976, 17287340, 19007248, ...16565220, 18669648, 20068231
S125 Phosphorylation HPRD 18691976, 17287340, 19691289, ...16565220, 18669648, 19007248, 20068231
T147 Phosphorylation HPRD 16565220
T179 Phosphorylation HPRD 19007248
S185 Phosphorylation HPRD 18691976, 19007248
S186 Phosphorylation HPRD 19007248, 16565220
S209 Phosphorylation HPRD 19007248
T210 Phosphorylation HPRD 20068231
S218 Phosphorylation HPRD 19007248
S250 Phosphorylation HPRD 19007248
S257 Phosphorylation HPRD 18669648
S292 Phosphorylation HPRD 20068231
S293 Phosphorylation HPRD 18691976, 19007248, 20068231, ...16565220
S310 Phosphorylation HPRD 18669648
T316 Phosphorylation HPRD 20068231
T338 Phosphorylation HPRD 18669648, 16565220
S358 Phosphorylation HPRD 18669648, 19691289
S359 Phosphorylation HPRD 18669648, 16565220
T361 Phosphorylation HPRD 18669648
T369 Phosphorylation HPRD 16964243, 16565220, 19007248, ...20068231, 19691289
T374 Phosphorylation HPRD 16565220, 19691289, 19007248
T386 Phosphorylation HPRD 19691289
S486 Phosphorylation HPRD 18691976, 18212344, 19007248, ...16565220, 18669648, 20068230, 17924679, 20068231, 19691289
T499 Phosphorylation HPRD 19691289
S542 Phosphorylation HPRD 16565220
S634 Phosphorylation HPRD 17525332
S646 Phosphorylation HPRD 20068231
S652 Phosphorylation HPRD 19007248, 16565220
S654 Phosphorylation HPRD 16565220
S738 Phosphorylation HPRD 19413330, 18691976, 16964243, ...18767875, 19664994, 19691289, 19007248, 17322306, 18669648, 19651622, 19664995, 18707149, 18452278, 19415658, 20068231, 18212344
S742 Phosphorylation HPRD 20068231
T743 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S370 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O14965 (AURKA) T287 Q9ULW0 (TPX2) unknown eFIP 21347367
Phosphorylation P35611 (ADD1) S726 Q9ULW0 (TPX2) unknown eFIP 29925526


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 L20 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S20 * Biomuta DOID:1612 / breast cancer [ tcga ]
K58 N58 Biomuta DOID:9256 / colorectal cancer [ tcga ]
T72 A72 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S110 * Biomuta DOID:4362 / cervical cancer [ tcga ]
S125 F125 Biomuta DOID:1324 / lung cancer [ cosmic ]
C198 * Biomuta DOID:363 / uterine cancer [ tcga ]
S252 G252 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S252 I252 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S285 C285 Biomuta DOID:1324 / lung cancer [ tcga ]
R288 Q288 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R288 L288 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K313 N313 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K313 R313 Biomuta DOID:2531 / hematologic cancer [ tcga ]
K348 R348 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S359 F359 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K420 N420 Biomuta DOID:363 / uterine cancer [ icgc, tcga ]
K477 N477 Biomuta DOID:363 / uterine cancer [ tcga ]
S539 L539 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K565 M565 Biomuta DOID:2531 / hematologic cancer [ tcga ]
K585 N585 Biomuta DOID:3571 / liver cancer [ icgc ]
K620 E620 Biomuta DOID:1324 / lung cancer [ cosmic ]
K641 Q641 Biomuta DOID:263 / kidney cancer [ tcga ]
K641 N641 Biomuta DOID:363 / uterine cancer [ tcga ]
T743 A743 Biomuta DOID:10283 / prostate cancer [ cosmic ]