iPTMnet Report for Q9ULT6 (ZNRF3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9ULT6 / ZNRF3_HUMAN
Protein Name E3 ubiquitin-protein ligase ZNRF3 precursor
Gene Name Name: ZNRF3
Synonyms:KIAA1133,RNF203;
Organism Homo sapiens (Human)

PRO ID PR:Q9ULT6
DAG View
PRO Name E3 ubiquitin-protein ligase ZNRF3 (human)
Definition An E3 ubiquitin-protein ligase ZNRF3 that is encoded in the genome of human.
Short Label hZNRF3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9ULT6 (ZNRF3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
K134 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
Y415 Phosphorylation PhosphoSitePlus
Y440 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
Y594 Phosphorylation PhosphoSitePlus
Y599 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S690 Phosphorylation PhosphoSitePlus
Y759 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049730 (hZNRF3/SigPep-/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K261 T261 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y440 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S441 F441 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S627 C627 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S690 F690 Biomuta DOID:4159 / skin cancer [ cosmic ]