iPTMnet Report for Q9ULQ1 (TPCN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9ULQ1 / TPC1_HUMAN
Protein Name Two pore channel protein 1
Gene Name Name: TPCN1
Synonyms:KIAA1169,TPC1;
Organism Homo sapiens (Human)

PRO ID PR:Q9ULQ1
DAG View
PRO Name two pore channel protein 1 (human)
Definition A two pore channel protein 1 that is encoded in the genome of human.
Short Label hTPCN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9ULQ1 (TPCN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K92 Ubiquitination PhosphoSitePlus
R354 Methylation PhosphoSitePlus
R361 Methylation PhosphoSitePlus
T382 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
T573 Phosphorylation PhosphoSitePlus
N611 N-Glycosylation GlyGen 24190977
N616 N-Glycosylation GlyGen 24190977
S766 Phosphorylation PhosphoSitePlus
S795 Phosphorylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
S812 Phosphorylation PhosphoSitePlus
T814 Phosphorylation PhosphoSitePlus
T816 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S58 L58 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K92 N92 Biomuta DOID:1324 / lung cancer [ cosmic ]
T382 P382 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T426 M426 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S569 G569 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
N611 Y611 Biomuta DOID:3571 / liver cancer [ cosmic ]
S812 Y812 Biomuta DOID:5041 / esophageal cancer [ cosmic ]