iPTMnet Report for Q9ULK4 (MED23)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9ULK4 / MED23_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 23
Gene Name Name: MED23
Synonyms:ARC130,CRSP3,DRIP130,KIAA1216,SUR2;
Organism Homo sapiens (Human)

PRO ID PR:Q9ULK4
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 23 (human)
Definition A mediator of RNA polymerase II transcription subunit 23 that is encoded in the genome of human.
Short Label hMED23
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9ULK4 (MED23) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K242 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
T512 Phosphorylation PhosphoSitePlus
T545 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K766 Ubiquitination PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
K920 Ubiquitination PhosphoSitePlus
K1050 Ubiquitination PhosphoSitePlus
K1082 Ubiquitination PhosphoSitePlus
K1132 Ubiquitination PhosphoSitePlus
S1176 Phosphorylation PhosphoSitePlus
C1295 Methylation IEDB 31844290
K1316 Ubiquitination PhosphoSitePlus
K1322 Ubiquitination PhosphoSitePlus
S1352 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T654 Phosphorylation HPRD 20068231
T666 Phosphorylation HPRD 20068231
S1350 Phosphorylation HPRD 18691976, 20068231
S1352 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
K300 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K300 Ubiquitination PhosphoSitePlus
T660 Phosphorylation HPRD 20068231
T672 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K291 E291 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T545 I545 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K905 N905 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1050 Q1050 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1352 P1352 Biomuta DOID:9256 / colorectal cancer [ cosmic ]