iPTMnet Report for Q9ULI3 (HEG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9ULI3 / HEG1_HUMAN
Protein Name Protein HEG homolog 1 precursor
Gene Name Name: HEG1
Synonyms:KIAA1237;
Organism Homo sapiens (Human)

PRO ID PR:Q9ULI3
DAG View
PRO Name protein HEG homolog 1 (human)
Definition A protein HEG homolog 1 that is encoded in the genome of human.
Short Label hHEG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9ULI3 (HEG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S36 O-Glycosylation GlyGen 25813380
S43 O-Glycosylation GlyGen 30459171, 25813380
T67 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 25813380, 22171320
T67 Phosphorylation PhosphoSitePlus
T77 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S81 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T91 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S96 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T146 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S147 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S150 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S154 O-Glycosylation GlyGen 30459171
N159 N-Glycosylation GlyGen   UniProt 16335952, 29391424
T161 O-Glycosylation GlyGen 30459171
T179 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
T194 O-Glycosylation GlyGen 25813380
T197 O-Glycosylation GlyGen 25813380
S198 O-Glycosylation GlyGen 30459171
S200 O-Glycosylation GlyGen 25813380
S205 O-Glycosylation GlyGen 30459171, 25813380
S212 O-Glycosylation GlyGen 25813380
T226 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T230 O-Glycosylation GlyGen 25813380
S232 O-Glycosylation GlyGen 25813380
T236 O-Glycosylation GlyGen 25813380
T236 Phosphorylation PhosphoSitePlus
S243 O-Glycosylation GlyGen 25813380
T254 O-Glycosylation GlyGen 25813380
T255 O-Glycosylation GlyGen 25813380
S259 O-Glycosylation GlyGen 30459171
S261 O-Glycosylation GlyGen 30459171
N279 N-Glycosylation GlyGen 29391424
N313 N-Glycosylation GlyGen 29391424
N314 N-Glycosylation GlyGen 23090970, 24190977
T328 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T333 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T336 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T342 O-Glycosylation GlyGen 25813380
S345 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T347 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S349 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380, ...30407017
S354 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T356 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T356 Phosphorylation PhosphoSitePlus
S363 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T367 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T368 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S369 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S375 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S377 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T388 O-Glycosylation GlyGen 30459171, 25813380
S400 O-Glycosylation GlyGen 30459171, 25813380
T401 O-Glycosylation GlyGen 30459171, 25813380
T441 O-Glycosylation GlyGen 25813380
S443 O-Glycosylation GlyGen 25813380
S445 O-Glycosylation GlyGen 25813380
T455 O-Glycosylation GlyGen 25813380
T492 O-Glycosylation GlyGen 30459171, 25813380
T500 O-Glycosylation GlyGen 25813380
S506 Phosphorylation PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
N520 N-Glycosylation GlyGen   UniProt 16335952, 23090970
S522 Phosphorylation PhosphoSitePlus
S529 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
S534 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T547 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S548 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S549 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T552 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T555 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S558 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S559 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T560 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T562 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
N574 N-Glycosylation GlyGen 29391424
N592 N-Glycosylation GlyGen 29391424
S599 O-Glycosylation GlyGen 25813380
S600 O-Glycosylation GlyGen 25813380
T606 O-Glycosylation GlyGen 25813380
S661 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S680 O-Glycosylation GlyGen 30459171
S689 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S690 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S694 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T695 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S715 O-Glycosylation GlyGen 30459171
S795 Phosphorylation IEDB 32387766
T803 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S818 Phosphorylation PhosphoSitePlus
T875 O-Glycosylation GlyGen 25813380
T875 Phosphorylation PhosphoSitePlus
T876 O-Glycosylation GlyGen 25813380
T876 Phosphorylation PhosphoSitePlus
S894 O-Glycosylation GlyGen 25813380
T895 O-Glycosylation GlyGen 25813380
S900 O-Glycosylation GlyGen 25813380
T901 O-Glycosylation GlyGen 25813380
T911 Phosphorylation PhosphoSitePlus
T922 Phosphorylation PhosphoSitePlus
T928 O-Glycosylation GlyGen 25813380
T929 O-Glycosylation GlyGen 25813380
T934 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S938 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S941 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T952 O-Glycosylation GlyGen 30459171
S956 O-Glycosylation GlyGen 30459171
N1080 N-Glycosylation GlyGen 29391424
T1082 Phosphorylation PhosphoSitePlus
N1101 N-Glycosylation GlyGen 29391424
N1122 N-Glycosylation GlyGen 29391424
S1293 Phosphorylation PhosphoSitePlus
Y1295 Phosphorylation PhosphoSitePlus
Y1298 Phosphorylation PhosphoSitePlus
K1300 Ubiquitination PhosphoSitePlus
N1317 N-Glycosylation GlyGen 29391424
S1319 Phosphorylation PhosphoSitePlus
Y1330 Phosphorylation PhosphoSitePlus
Y1331 Phosphorylation PhosphoSitePlus
S1332 Phosphorylation PhosphoSitePlus
Y1347 Phosphorylation PhosphoSitePlus
Y1350 Phosphorylation PhosphoSitePlus
T1351 Phosphorylation PhosphoSitePlus
S1359 Phosphorylation PhosphoSitePlus
Y1380 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S96 F96 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S147 F147 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S154 L154 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:363 / uterine cancer [ cosmic, icgc ]
S198 F198 Biomuta DOID:4159 / skin cancer [ cosmic ]
S205 L205 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S243 L243 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
N314 D314 Biomuta [ cosmic ]
T342 M342 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T347 M347 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S354 I354 Biomuta DOID:1612 / breast cancer [ cosmic ]
S363 C363 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S377 F377 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S445 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S445 L445 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T500 A500 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S508 L508 Biomuta [ cosmic ]
S510 F510 Biomuta DOID:363 / uterine cancer [ icgc ]
S510 P510 Biomuta DOID:263 / kidney cancer [ cosmic ]
S529 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S529 L529 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T555 N555 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S664 F664 Biomuta DOID:4159 / skin cancer [ icgc ]
S680 C680 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S689 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S690 L690 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S694 L694 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T875 S875 Biomuta [ cosmic ]
T876 I876 Biomuta DOID:4159 / skin cancer [ cosmic ]
N1080 K1080 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1332 L1332 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y1380 C1380 Biomuta DOID:3571 / liver cancer [ cosmic ]