iPTMnet Report for Q9UL54 (TAOK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UL54 / TAOK2_HUMAN
Protein Name Serine/threonine-protein kinase TAO2
Gene Name Name: TAOK2
Synonyms:KIAA0881,MAP3K17,PSK,PSK1;ORFNames:UNQ2971/PRO7431;
Organism Homo sapiens (Human)

PRO ID PR:Q9UL54
DAG View
PRO Name serine/threonine-protein kinase TAO2 (human)
Definition A serine/threonine-protein kinase TAO2 that is encoded in the genome of human.
Short Label hTAOK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UL54 (TAOK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
K11 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S181 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 19369195, 17158878
S181 Phosphorylation Q9UL54 (TAOK2) neXtProt 17158878
T185 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
Y338 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y426 Phosphorylation PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
K673 Ubiquitination PhosphoSitePlus
K722 Ubiquitination PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
S777 Phosphorylation PhosphoSitePlus   UniProt 18691976
S825 Phosphorylation PhosphoSitePlus   UniProt 20068231
S827 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
H1011 Phosphorylation UniProt 19369195
R1126 Methylation PhosphoSitePlus
R1133 Methylation PhosphoSitePlus
S1210 O-Glycosylation GlyGen 30620550
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 18691976
S437 Phosphorylation HPRD 18691976
S473 Phosphorylation HPRD 19691289
S486 Phosphorylation HPRD 18691976
S777 Phosphorylation HPRD 18691976
S825 Phosphorylation HPRD 18691976, 20068231
S827 Phosphorylation HPRD 18691976, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 18691976
S181 Phosphorylation neXtProt 17158878
S181 Phosphorylation Q9UL54-2 (TAOK2) neXtProt 17158878
Y309 Phosphorylation PhosphoSitePlus
S437 Phosphorylation HPRD 18691976
S473 Phosphorylation HPRD 19691289
S486 Phosphorylation HPRD 18691976
S742 Phosphorylation PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
R870 Methylation PhosphoSitePlus
R876 Methylation PhosphoSitePlus
S889 Phosphorylation PhosphoSitePlus
S894 Phosphorylation PhosphoSitePlus
R948 Methylation PhosphoSitePlus
R1000 Methylation PhosphoSitePlus
S1002 Phosphorylation PhosphoSitePlus
R1007 Methylation PhosphoSitePlus
S1011 Phosphorylation PhosphoSitePlus
S1014 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1031 Phosphorylation neXtProt 17988630
S1031 Phosphorylation Q16539 (MAPK14) neXtProt 17988630
R1032 Methylation PhosphoSitePlus
Y1048 Phosphorylation PhosphoSitePlus


Q9UL54 (TAOK2) as PTM Enzyme



Substrate Site Score Source PMID
P19419-1 (ELK1) S383 HPRD   Signor 12665513
P46734 (MAP2K3) S218 Signor 11279118
P52564 (MAP2K6) S207 neXtProt   Signor 10497253, 11279118, 15458637
P52564 (MAP2K6) T211 neXtProt 10497253, 15458637
Q9UL54-2 (TAOK2) S181 neXtProt 17158878


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 N9 Biomuta [ cosmic ]
K11 N11 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S181 F181 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T185 A185 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y426 C426 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y430 S430 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S486 F486 Biomuta DOID:1324 / lung cancer [ cosmic ]
K746 N746 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S825 I825 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S889 F889 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R948 H948 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] [ cosmic ]
S1011 L1011 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
R1126 P1126 Biomuta DOID:1324 / lung cancer [ cosmic ]