iPTMnet Report for Q9UL51 (HCN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UL51 / HCN2_HUMAN
Protein Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Gene Name Name: HCN2
Synonyms:BCNG2;
Organism Homo sapiens (Human)

PRO ID PR:Q9UL51
DAG View
PRO Name potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (human)
Definition A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human.
Short Label hHCN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UL51 (HCN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S81 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus
Y476 Phosphorylation RLIMS-P+   Signor 16079136, 26280531
Y476 Phosphorylation P12931 (SRC) RLIMS-P+   Signor 16079136, 26280531
T576 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
S668 Phosphorylation neXtProt 21347269
S668 Phosphorylation Q13237 (PRKG2) neXtProt 21347269
Y697 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
S779 Phosphorylation PhosphoSitePlus
S786 Phosphorylation PhosphoSitePlus
T792 O-Glycosylation GlyGen 28657654
T792 Phosphorylation HPRD   phospho.ELM 18669648
Y795 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T851 Phosphorylation PhosphoSitePlus
S860 Phosphorylation PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S179 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S185 G185 Biomuta DOID:1324 / lung cancer [ cosmic ]
S314 F314 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y476 H476 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]