Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UL46 / PSME2_HUMAN
Protein Name Proteasome activator complex subunit 2
Gene Name Name: PSME2
Organism Homo sapiens (Human)

PRO ID PR:Q9UL46
DAG View
PRO Name proteasome activator complex subunit 2 (human)
Definition A proteasome activator complex subunit 2 that is encoded in the genome of human.
Short Label hPSME2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UL46 (PSME2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
K3 Methylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
R8 Methylation PhosphoSitePlus
S10 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 20068231
K15 Ubiquitination PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
T162 Phosphorylation HPRD 20068231
K166 Ubiquitination PhosphoSitePlus
K180 Acetylation PhosphoSitePlus
Y187 Phosphorylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S10 C10 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S102 F102 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K180 N180 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
Y199 C199 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y239 C239 Biomuta DOID:10283 / prostate cancer [ cosmic ]