iPTMnet Report for Q9UKV8 (AGO2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKV8 / AGO2_HUMAN
Protein Name Protein argonaute-2
Gene Name Name: AGO2
Synonyms:EIF2C2;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKV8
DAG View
PRO Name protein argonaute-2 (human)
Definition A protein argonaute-2 that is encoded in the genome of human.
Short Label hAGO2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKV8 (AGO2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K62 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T118 Phosphorylation IEDB 35494241
S153 Phosphorylation PhosphoSitePlus
C188 S-Nitrosylation dbSNO 26338901
K248 Ubiquitination PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
K317 Acetylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
T337 Phosphorylation PhosphoSitePlus
Y338 Phosphorylation PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S387 Phosphorylation P49137 (MAPKAPK2) , Q9Y243 (AKT3) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24030283, 28683311, 27117408, ...23186163, 33199684, 20626350, 18476811, 23603119, 28114302, 30771383, 30154469, 18613814, 29712715, 29123165, 28877994
T390 Phosphorylation PhosphoSitePlus
Y393 Phosphorylation P00533 (EGFR) PhosphoSitePlus   RLIMS-P 32499547, 23636329, 31981897, ...32446890, 29253018, 28877994
K402 Sumoylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
T526 Phosphorylation PhosphoSitePlus
Y529 Phosphorylation PhosphoSitePlus   RLIMS-P 26379499, 31981897
K533 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
C691 Methylation IEDB 31844290
K720 Ubiquitination PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
Y749 Phosphorylation PhosphoSitePlus   RLIMS-P 31981897
S752 Phosphorylation PhosphoSitePlus
T759 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus   RLIMS-P 26443379
S824 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28114302, 33199684
S828 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 28114302
T830 Phosphorylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28114302
S834 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28114302, 33199684
K844 Ubiquitination PhosphoSitePlus
T852 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T251 Phosphorylation HPRD 20068231
S387 Phosphorylation HPRD 19664994
S824 Phosphorylation HPRD 18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9BWF3 (RBM4) S309 Q9UKV8 (AGO2) unknown eFIP 23897118
Phosphorylation Q9H0Z9 (RBM38) S195 Q9UKV8 (AGO2) decreased_association eFIP 30567739
Phosphorylation Q9UKV8 (AGO2) S387 Q9UGP4 (LIMD1) unknown eFIP 28683311
Phosphorylation Q9UKV8 (AGO2) S387 Q8NDV7 (TNRC6A) increased_association eFIP 28683311
Phosphorylation Q9UKV8 (AGO2) Y393 Q9UPY3 (DICER1) decreased_association eFIP 31981897


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T303 S303 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T337 S337 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T357 M357 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y393 H393 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T526 M526 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K550 N550 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K566 N566 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K655 T655 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C691 F691 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S831 P831 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]