iPTMnet Report for Q9UKV5 (AMFR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKV5 / AMFR_HUMAN
Protein Name E3 ubiquitin-protein ligase AMFR
Gene Name Name: AMFR
Synonyms:RNF45;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKV5
DAG View
PRO Name E3 ubiquitin-protein ligase AMFR (human)
Definition An E3 ubiquitin-protein ligase AMFR that is encoded in the genome of human.
Short Label hAMFR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKV5 (AMFR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C104 Methylation IEDB 31844290
K353 Ubiquitination PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
S509 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S516 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S522 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S523 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T530 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
S542 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 23186163, 18669648
T548 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
S601 Phosphorylation HPRD   phospho.ELM 18669648
S602 Phosphorylation PhosphoSitePlus
T623 Phosphorylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S507 L507 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
T548 M548 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K586 N586 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]