Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKV3 / ACINU_HUMAN
Protein Name Apoptotic chromatin condensation inducer in the nucleus
Gene Name Name: ACIN1
Synonyms:ACINUS,KIAA0670;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKV3
DAG View
PRO Name apoptotic chromatin condensation inducer in the nucleus (human)
Definition An apoptotic chromatin condensation inducer in the nucleus that is encoded in the genome of human.
Short Label hACIN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKV3 (ACIN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
R8 Methylation PhosphoSitePlus
R14 Methylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
R29 Methylation PhosphoSitePlus
K81 Methylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
R87 Methylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
K103 Methylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K113 Methylation PhosphoSitePlus
S115 Phosphorylation HPRD   PhosphoSitePlus 20068231
T116 Phosphorylation HPRD   PhosphoSitePlus 20068231
S125 Phosphorylation PhosphoSitePlus
S132 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18077418, 23186163, 20068231
S135 Phosphorylation HPRD   PhosphoSitePlus 20068231
K138 Ubiquitination PhosphoSitePlus
K143 Methylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S166 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S169 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569, 18452278
S189 Phosphorylation HPRD 17081983
S190 Phosphorylation HPRD 17081983
S199 Phosphorylation HPRD 17081983
S206 Phosphorylation HPRD   phospho.ELM 18669648
S208 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340
S210 Phosphorylation PhosphoSitePlus   UniProt 21406692
S216 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...19691289, 18452278, 19651622, 19367720, 18669648, 24275569, 18707149, 20166139, 23186163, 18318008, 19415658, 20068231, 18212344
S228 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S229 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K238 Acetylation PhosphoSitePlus
S240 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18452278, 19651622, 18669648, 20166139, 20068231, 16964243
S243 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18452278, 19651622, 18669648, 20166139, 20068231, 17081983
T254 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...19007248, 18452278, 18669648, 17287340, 19690332, 20068231
S256 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K268 Sumoylation PhosphoSitePlus
T269 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S295 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K302 Ubiquitination PhosphoSitePlus
K315 Sumoylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus   UniProt 21406692
S328 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19651622, 18669648, 20068231
R336 Methylation PhosphoSitePlus
T341 Phosphorylation HPRD 17081983
S343 Phosphorylation PhosphoSitePlus
K359 Acetylation PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
T364 Phosphorylation HPRD   PhosphoSitePlus 20058876
S365 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 20058876, 17081983, ...19664994, 15302935, 19007248, 19691289, 19651622, 18669648, 24275569, 23186163, 20068231
S376 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S377 Phosphorylation PhosphoSitePlus
S384 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17287340, ...17081983, 17322306, 18669648, 14729942, 20068231
S386 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 17287340, ...17081983, 15302935, 19651622, 18669648, 20166139, 23186163, 20068231
S388 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 16083285, 17287340, ...17081983, 15302935, 19651622, 20166139, 18669648, 14729942, 23186163, 20068231
T393 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 21406692, 17081983, ...17322306, 18669648, 20068231
S400 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231, 23186163, 19690332, ...24275569
T408 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17081983, 19664995, ...19651622, 18669648, 20068231
S410 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 19664995, 18452278, 19651622, 18669648, 19415658, 24275569, 19690332, 20068231
T414 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 15302935, ...18452278, 19651622, 18669648, 24275569, 19690332, 20068231
T420 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S424 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231, ...18220336
S425 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 17081983, 18220336, ...18452278, 18669648
S434 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18452278, 20068231, ...18220336
S453 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336, 20058876, ...18452278, 18669648, 24275569, 20068231
T457 Phosphorylation HPRD   PhosphoSitePlus 17081983
T461 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20068231
S478 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20058876, 19690332, 24275569, ...19664995
S481 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
S490 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18452278, 19651622, 18669648, 24275569, 18707149, 20166139, 19690332, 20068231
S499 Phosphorylation HPRD   PhosphoSitePlus 20166139
K506 Ubiquitination PhosphoSitePlus
Y512 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S513 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K516 Ubiquitination PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus   UniProt 23186163
R524 Methylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
K532 Sumoylation PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S561 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18212344, 18669648, ...24275569, 18707149, 20166139, 23186163, 20068231
T563 Phosphorylation HPRD   PhosphoSitePlus 20068231
S583 Phosphorylation PhosphoSitePlus
S584 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
S599 Phosphorylation HPRD 19651622
S601 Phosphorylation HPRD   PhosphoSitePlus 19651622
S605 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 20068231
R624 Methylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
K654 Methylation PhosphoSitePlus   UniProt 18438403
S655 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...23186163, 17081983, 19651622, 18669648, 20166139, 20068231
S657 O-Glycosylation GlyGen 23301498, 32119511, 28510447, ...26853435, 29351928
S657 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 19691289, ...23186163, 17081983, 18767875, 15302935, 19007248, 19664995, 19651622, 17322306, 18669648, 20166139, 20068231, 20068230
S661 O-Glycosylation GlyGen 23301498, 32119511, 28510447, ...26853435, 29351928
S661 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935, 19007248
S664 Phosphorylation HPRD   PhosphoSitePlus 18452278
T666 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
Y668 Phosphorylation HPRD   phospho.ELM 18669648
T671 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S675 Phosphorylation HPRD   PhosphoSitePlus 19413330
S676 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 15302935
T682 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...15302935, 18452278, 18669648, 20068231
C691 S-Nitrosylation dbSNO 26338901
T697 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
T699 Phosphorylation HPRD 20068231
S702 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S710 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16083285, 23186163, ...17081983, 18767875, 18077418, 19691289, 18452278, 19651622, 19367720, 18669648, 24275569, 18707149, 20166139, 17287340, 17924679, 20068231, 18212344
S714 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 19651622, ...18669648, 20068231, 17924679
K717 Acetylation PhosphoSitePlus   UniProt 19608861
T720 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S729 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 17287340, 18212344, ...21406692, 18452278, 19651622, 20166139, 20068231, 17924679
T744 Phosphorylation HPRD   PhosphoSitePlus 18077418
T748 Phosphorylation PhosphoSitePlus
T751 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
S814 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 20068231
S815 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K818 Ubiquitination PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
S825 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18212344, 24275569, 20166139
S828 Phosphorylation HPRD   PhosphoSitePlus 20068231
T830 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K831 Ubiquitination PhosphoSitePlus
S838 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17287340, ...18212344, 19664995, 18669648, 24275569, 23186163, 19690332, 20068231
T840 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
K860 Ubiquitination PhosphoSitePlus
K861 Ubiquitination PhosphoSitePlus
S863 Phosphorylation HPRD   PhosphoSitePlus 18212344
S865 Phosphorylation PhosphoSitePlus
S870 O-Glycosylation GlyGen 23301498, 32119511, 28510447, ...26853435, 29351928
S895 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18220336, 18452278, 19651622, ...18669648, 20068231
S898 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18220336, 18452278, 19651622, ...18669648, 24275569
T902 Phosphorylation PhosphoSitePlus
T976 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
T978 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S981 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 20068231
S983 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 20068231
K986 Ubiquitination PhosphoSitePlus
S987 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S990 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19690332, 20068231
T992 Phosphorylation PhosphoSitePlus
T999 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 18220336, 20058876, 19664994, 15302935, 19664995, 19651622, 19367720, 18669648, 17322306, 24275569, 18767875, 20166139, 17924679, 19415658, 20068231, 16964243
K1029 Ubiquitination PhosphoSitePlus
K1047 Ubiquitination PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
T1106 Phosphorylation PhosphoSitePlus
S1161 Phosphorylation PhosphoSitePlus
S1176 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 17081983
S1178 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 17081983
S1180 Phosphorylation P78362 (SRPK2) , P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18559500, 17287340, 16177823, ...21056976, 19592491
K1209 Ubiquitination PhosphoSitePlus
K1219 Ubiquitination PhosphoSitePlus
Y1225 Phosphorylation PhosphoSitePlus
T1230 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1232 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1237 Ubiquitination PhosphoSitePlus
K1253 Methylation PhosphoSitePlus
S1284 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S1325 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S1327 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
S1329 Phosphorylation P31749 (AKT1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 19651622, 17081983, 20068231, ...16177823
S1331 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 17081983
T1332 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S453 Phosphorylation PhosphoSitePlus
S604 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S825 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
S862 Phosphorylation PhosphoSitePlus
S882 Phosphorylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R14 L14 Biomuta DOID:1909 / melanoma [ tcga ]
S115 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S135 N135 Biomuta DOID:0070003 / blastoma [ cosmic ]
S199 T199 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
S208 L208 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S208 * Biomuta DOID:3571 / liver cancer [ icgc ]
T326 K326 Biomuta DOID:3571 / liver cancer [ icgc ]
S328 F328 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T364 A364 Biomuta DOID:1612 / breast cancer [ cosmic ]
S365 Y365 Biomuta DOID:4362 / cervical cancer [ tcga ]
S376 F376 Biomuta DOID:1324 / lung cancer [ cosmic ]
S376 Y376 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3571 / liver cancer [ icgc ]
S384 P384 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S388 F388 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S400 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S410 I410 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S425 C425 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S453 A453 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T461 A461 Biomuta DOID:363 / uterine cancer [ tcga ]
S478 F478 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y512 F512 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K532 Q532 Biomuta DOID:1324 / lung cancer [ tcga ]
S585 F585 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S588 T588 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S661 C661 Biomuta DOID:1612 / breast cancer [ tcga ]
S661 F661 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S664 R664 Biomuta DOID:3571 / liver cancer [ icgc ]
T666 A666 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T671 S671 Biomuta DOID:2531 / hematologic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
C691 S691 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
T697 I697 Biomuta DOID:2394 / ovarian cancer [ icgc ]
S714 L714 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S714 * Biomuta DOID:3571 / liver cancer [ icgc ]
S729 R729 Biomuta DOID:3571 / liver cancer [ icgc ]
S754 P754 Biomuta DOID:363 / uterine cancer [ tcga ]
S815 L815 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S825 F825 Biomuta DOID:1115 / sarcoma [ tcga ]
T840 K840 Biomuta DOID:3571 / liver cancer [ icgc ]
S863 F863 Biomuta DOID:363 / uterine cancer [ tcga ]
S895 C895 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T902 K902 Biomuta DOID:3571 / liver cancer [ icgc ]
K986 Q986 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S987 A987 Biomuta DOID:10534 / stomach cancer [ tcga ]
S990 F990 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K1029 E1029 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S1178 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S1232 G1232 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S1232 I1232 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S1284 N1284 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1325 R1325 Biomuta DOID:3571 / liver cancer [ icgc ]
S1327 R1327 Biomuta DOID:1324 / lung cancer [ tcga ]
S1329 N1329 Biomuta DOID:1909 / melanoma [ cosmic ]
S1331 G1331 Biomuta DOID:1909 / melanoma [ cosmic ]