iPTMnet Report for Q9UKU7 (ACAD8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKU7 / ACAD8_HUMAN
Protein Name Isobutyryl-CoA dehydrogenase, mitochondrial precursor
Gene Name Name: ACAD8
Synonyms:ARC42,IBD;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKU7
DAG View
PRO Name isobutyryl-CoA dehydrogenase, mitochondrial (human)
Definition An isobutyryl-CoA dehydrogenase, mitochondrial that is encoded in the genome of human.
Short Label hACAD8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKU7 (ACAD8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T26 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K178 Acetylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K231 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S216 L216 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S261 N261 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K303 N303 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]