iPTMnet Report for Q9UKS6 (PACSIN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKS6 / PACN3_HUMAN
Protein Name Protein kinase C and casein kinase substrate in neurons protein 3
Gene Name Name: PACSIN3
Organism Homo sapiens (Human)

PRO ID PR:Q9UKS6
DAG View
PRO Name protein kinase C and casein kinase substrate in neurons protein 3 (human)
Definition A protein kinase C and casein kinase substrate in neurons protein 3 that is encoded in the genome of human.
Short Label hPACSIN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKS6 (PACSIN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K70 Ubiquitination PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S276 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18452278, ...19651622, 18669648, 24275569, 20166139, 20068231
S303 Phosphorylation PhosphoSitePlus
S319 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18767875, 19664994, 18452278, 19651622, 18669648, 24275569, 20166139, 20068231
T324 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 18452278
T326 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S327 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
T331 Phosphorylation HPRD   PhosphoSitePlus 18452278
T335 Phosphorylation HPRD 17081983
S341 Phosphorylation HPRD   PhosphoSitePlus 17081983
S344 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 18452278
T347 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17081983, 20068231
S354 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18452278, ...19651622, 18669648, 24275569, 20166139, 20068231
S358 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278
K361 Ubiquitination PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
S383 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 19415658, 18669648, ...18452278, 19690332, 20068231
S394 Phosphorylation PhosphoSitePlus
C402 S-Nitrosylation dbSNO 26338901
Y418 Phosphorylation PhosphoSitePlus
C421 S-Nitrosylation dbSNO 26338901


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K141 N141 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S178 N178 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S303 T303 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S354 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y374 S374 Biomuta [ cosmic ]
Y418 * Biomuta DOID:1324 / lung cancer [ cosmic ]