iPTMnet Report for Q9UKK9 (NUDT5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9UKK9 / NUDT5_HUMAN
Protein Name ADP-sugar pyrophosphatase
Gene Name Name: NUDT5
Synonyms:NUDIX5;ORFNames:HSPC115;
Organism Homo sapiens (Human)

PRO ID PR:Q9UKK9
DAG View
PRO Name ADP-sugar pyrophosphatase (human)
Definition An ADP-sugar pyrophosphatase that is encoded in the genome of human.
Short Label hNUDT5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9UKK9 (NUDT5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 21406692, 22223895, ...20068231
S3 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163
T7 Phosphorylation HPRD   PhosphoSitePlus 20068231
S9 Phosphorylation HPRD 20068231
S10 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K14 Ubiquitination PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
K27 Acetylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K33 Acetylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K42 Acetylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27257257, 31510016
S48 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
Y74 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
K175 Ubiquitination PhosphoSitePlus
K205 Methylation PhosphoSitePlus
K210 Acetylation PhosphoSitePlus   UniProt 19608861
K210 Ubiquitination PhosphoSitePlus
K218 Acetylation PhosphoSitePlus   UniProt 19608861
K218 Methylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y16 C16 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T45 N45 Biomuta DOID:3571 / liver cancer [ cosmic ]
K175 M175 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]